Category Archives: Medicine

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Does Hypoxia Prevent Cancer?

Summit Daily News recently published an article based on research in the Journal of the American Medical Association showing Summit County                                                                                                       with the lowest cancer rate in the nation FOR 30 YEARS. Are people moving away when they get cancer? No, they are treated in Vail, Denver                                                                                                      and now the St. Anthony Summit Medical Center.  Do we have fewer older people? No, there is a large percentage of retired residents.

The report shows stark differences in regional cancer death rates : detailed estimates for deaths from nearly 30 types of cancer in all 3,100 U.S. counties for over 35 years.From 1980 to 2014, the U.S. death rate per 100,000 people for all cancers combined dropped from about 240 to 192 — a 20 percent decline. More than 19 million Americans died from cancer during that time, the study found. Healthy lifestyle with low rates of obesity and smoking and increased physical activity contribute to low cancer rates in the mountains.

The picture was rosiest the Colorado ski country, where cancer deaths per 100,000 residents dropped by almost half, from 130 in 1980 to just 70 in 2014;

drugs and altitude:

Consensus by International Federation on Drug Use at High Altitude

New Rochelle, NY, October 25, 2016—Drug taking at high altitude is variably intended to enhance performance, prevent or alleviate the debilitating effects of altitude, or for pleasurable use. In some cases, certain drugs can be advantageous and even life-saving, but many drugs lack evidence of benefit and carry risks of side effects or interactions. The International Climbing and Mountaineering Federation (UIAA) has published evidence-based guidelines advising on the safe use of alcohol, steroids, oxygen, erythropoietin, and many other types of drugs in mountain environments in an article in High Altitude Medicine & Biology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free online on the High Altitude Medicine & Biology website.

An international team of researchers from Kuwait, Austria, United Kingdom, Germany, Switzerland, Nepal, Spain, France, and the Netherlands, led by David Hillebrandt, MB, BS, President, UIAA Medical Commission, coauthored the article entitled “Drug Use and Misuse in the Mountains: An UIAA MedCom-Consensus Guide for Medical Professionals.” They conducted an extensive review of the medical literature, trials, observational studies, and case series to assess the evidence available for drugs commonly used by mountain climbers. Their conclusions and recommendations cover a broad range of drug types including alcohol, anabolic agents such as androgenic steroids, adrenergic agonists, beta-blocking agents, erythropoietin, oxygen, glucocorticosteroids, benzodiazepines, and stimulants such as amphetamines.

“The use of drugs beyond those proven effective in preventing and treating high altitude illnesses remains very controversial among both physicians and climbers,” says Erik R. Swenson, MD, Editor-in-Chief of High Altitude Medicine & Biology and Professor, Division of Pulmonary and Critical Care Medicine, Veterans Administration Puget Sound Healthcare System. “This broad and comprehensive review of the myriad drugs used for various purposes in climbing will be useful to all concerned in decision-making about their use, determining the level of supportive evidence, and importantly their potential costs and adverse effects.”

High-Altitude Lung Edema Can Mimic Pneumonia in Kids, Even Without Travel by Rob Goodier

Dr. Chris has the medical community talking about HAPE!!!

“Health providers should advise patients who live at or travel to high altitude to have a pulse oximeter and check their oxygen levels if they are unwell,” the study’s author, Dr. Christine Ebert-Santos at the Ebert Family Clinic in Frisco, Colorado, told Reuters Health…

Click the link to read more:

High-Altitude Lung Edema Can Mimic Pneumonia in Kids, Even Without Travel by Rob Goodier

http://www.medscape.com/viewarticle/867210

Those precious epi-pens at altitude

With all the news about the 400% price increase in epi-pens, we don’t want to waste them. So what if we are backpacking at high altitude and eat some peanut butter by mistake in our energy bar? Then our face swells up like a chipmunk and we start to wheeze? We whip out the epi-pen from the external pocket of our pack only to find out it is frozen!!  Oh, oh. What do we do now? Good news! at the 7th World Congress of Mountain and Wilderness Medicine in Telluride we heard the exact scenario described. It happened to a scientist, who then did a study to measure the effectiveness of the epi-pen after freezing and thawing. It still worked! So don’t throw out your frozen epinephrine. thaw and use.

Another tip: if you can’t afford the new price of the epi-pen, maybe your physician could prescribe injectable epi with a syringe to have on hand.

Reflection to MRHAPE in the Mountains: Resident High Altitude Pulmonary Edema

In beginning my Physician Assistant rotation at Ebert Family Clinic I was introduced to the exciting research of Christine Ebert-Santos, MD.  The research surrounded a condition known as High Altitude Pulmonary Edema (HAPE). In growing up at altitude myself, at 6,926 feet in Jamestown Colorado, I have had some exposure to the effects of high altitude. Acute Mountain Sickness (AMS) is a condition that I am more familiar with and in reading Dr. Ebert-Santos’ research it became clear to me that HAPE is a more severe complication to those ascending to or living at altitude, especially if they develop an initial respiratory illness. In her paper Dr. Ebert-Santos describes several pediatric case studies that demonstrate the characteristics of this treatable condition. These patients presented with tachycardia (fast heart rate), tachypnea (fast breathing), decreased oxygen saturation, and rales (abnormal breath sound).  Many of the children described were seen directly after an initiating illness such as the Flu. While seen in the clinic, or during admission to the hospital, these patients were treated with oxygen. The fact that HAPE can be treated with something as simple as oxygen is noteworthy.

Through her research Dr. Ebert-Santos has demonstrated that HAPE should be considered in all pediatric patients presenting to clinics  or emergency rooms at altitude with hypoxia (decreased oxygen saturation) and a recent viral illness. Through placing HAPE in their differential diagnosis, clinicians can avoid giving excessive inhaled steroid treatments and unneeded antibiotics. Awareness of the prevalence of this disease in both travelers and residents alike ensures a decrease in the incidence of unfavorable outcomes from this potentially fatal condition.

Submitted by Kelly Kyte, Physicians Assistant Student from Red Rocks Community College Fall Rotation 2016

“Home Remedy” by Ted Katauskas

Colorado Summit Magazine Summer-Fall 2016

In the Summer/Fall 2016 issue of Colorado Summit there is an interesting article entitled “Home Remedy” by Ted Katauskas.  A company, called Altitude Control Technologies, in Denver can install an air separator that continuously controls the amount of oxygen in a room based on barometric pressure and people entering and exiting that room.  So far, these devices have been used commercially and are now beginning to be used in high-priced dream homes.  There are medical implications of this technology for possible treatment of high altitude illnesses such as hypoxia or HAPE (High Altitude Pulmonary Edema).  For children, the implications would be adequate perfusion of oxygen to the organs to carry out life’s functions and promote healthy growth.  Imagine being able to treat hypoxia in the home by simply the push of a button.  Currently, this technology is very expensive.  It does beg the question, could an air separator be subsidized by insurance, or added into the construction of a new home?  Certainly, this technology holds promise for possible future treatment. 

Submitted by Joe Brath, NP Student from Georgetown University rotating Summer 2016

Live High Train Low- What’s an athlete to do?

I just came across this study in the literature from a couple years ago

Optimizing Altitude for Live High-Train

Low (LHTL) Training

Chapman et al (2013) hypothesized that athletes living at

higher altitudes would experience greater improvements in sea

level performance, secondary to greater hematological acclimatization,

compared to athletes living at lower altitudes. After

4 weeks of group sea level training and testing, 48 collegiate

distance runners (32 men, 16 women) were randomly assigned

to one of four living altitudes (1780m, 2085m, 2454m, or

2800 m). All athletes trained together daily at a common altitude

from 1250m to 3000m following a modified LHTL

model. Subjects completed hematological, metabolic and

performance measures at sea level before and after altitude

training. Upon return from altitude, 3000m time-trial performance

was only significantly improved in groups living at the

middle two altitudes. EPO remained elevated after 72 h except

in the 1780m group. Erythrocyte volume was significantly

higher in all groups but not different between groups. These

data suggest that a 4 week LHTL altitude camp at 2000m to

2500m is optimal for sea level performance.

 

HIGH ALTITUDE MEDICINE & BIOLOGY

Volume 15, Number 1, 2014

ª Mary Ann Liebert, Inc.

DOI: 10.1089/ham.2014.1513

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