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The Plants We Need Are There: A Naturopathic Approach to Acute Mountain Sickness

Acetazolamide is already known for its success with treating Acute Mountain Sickness (AMS) and helping patients with their transition to higher altitudes, but what other options are available? What about those who don’t want a prescription, that are looking for other alternatives to help them with AMS and being at high altitude?

During my time in Frisco, Colorado (9000’/2743 m) I was fortunate enough to interview two resident Naturopathic Doctors. Mountain River Naturopathic Clinic on Main Street of this little mountain town is a wonderful oasis for anyone in Colorado’s Summit County looking for alternative care and treatment for their mind and body.

Dr. Kimberly Nearpass, ND and Dr. Justin Pollack, ND took the time to educate Dr. Chris Ebert-Santos, my classmate Rachel Mader, and myself about all the naturopathic remedies available for AMS and residents at altitude.

Tell us about Naturopathic medicine and why you picked this path of medicine?

Dr. Kimberly Nearpass: I thought I was going to be an OBGYN and then I did more research. I talked to doctors, midwives and herbalists and found that the Western medicine model didn’t feel right to me. So I thought, “Do I go to medical school and try to operate functionally from the inside or do I find another track?” I did not know about naturopathic medicine until a few years later. I took some time off; I traveled and went to the Peace Corps and then I discovered naturopathic medicine and loved it. I had lived in Ecuador in the rainforest as a naturalist guide so I learned a lot about traditional medicine that way. I learned a lot about traditional medicine when I lived in rural Africa as well. Living in these rural areas and watching the indigenous people — and they certainly use modern medicine — but they did not have a lot of access. Especially in the rainforest, they were using a lot of plants and I was fascinated by that. But I still wanted the medical training. Then I discovered naturopathic school. So, it’s four years of medical school, we get the medical training, but we also have that more holistic, natural, herbal based approach.

What naturopathic remedies are available for acute mountain sickness (AMS)?

Dr. Nearpass: So I will tell you Acli-Mate is our go-to. I’m not tied to this product, a friend of mine, it is her company, she is a naturopathic doctor in Gunnison. She formulated this, she started it out as a high-altitude electrolyte drink. Everybody that comes in our door, we start with this. This stuff works AMAZING. We rarely have to go anywhere else. I think the combination of the electrolytes and that it is hydrating has a great benefit. It helps with the headache and the nausea. For mild to moderate symptoms of AMS it is incredible. What we do is if we have family coming to visit from sea level is we have them start drinking it before they come.

Acli-Mate is found to be highly effective at helping people who are suffering from AMS. The blend includes herbs Ginkgo biloba and Rhodiola, both of which have proven effective in preventing and treating altitude related sickness. Both herbs seem to improve circulation, especially through cerebral vessels, and cellular energy function through improved uptake and utilization of oxygen, reducing toxic brain edema. Ginkgo has also been shown to inhibit platelet clumping, keeping red blood cells evenly dispersed, which improves delivery of oxygen to tissues, while Rhodiola appears to help the body deal with stress.

Nutrients in Acli-Mate: Vitamin C, and many of the B vitamins: thiamin (B1), riboflavin (B2), niacin (B3), pantothene (B5) and cobolamin (B12).

Acli-Mate in a variety of applications.

Have you noticed that when you have patients drink it before they arrive at high altitude, they have a better outcome?

Dr. Nearpass: Yes. And I have a patient who is 70 now and 5-10 years ago she went with some girlfriend to hike Mount Kilimanjaro. She had all her girlfriends take it and emailed me after saying, “We all did great!” And I don’t want to put all my eggs in one basket but this is almost always all we need.

Dr. Justin Pollack: There is something about that blend of Rhodiola, Ginkgo and the B vitamins that seems to work. We’ve had tons of people use it clinically.

Dr. Nearpass: For other options, I think Rhodiola is a good one. It’s interesting to me because Rhodiola grows in Mongolia, it grows in high altitude. One of the things we talk about in herbal medicine is often the plants we need are there. For example, dandelion root grows everywhere and it is good for liver detox and helps with hepatic function. So, it is interesting to me that dandelion is popping up on the side of the highways and in areas that we could probably use a little cleansing and detoxing.

Dr. Chris Ebert-Santos: What about Coca?

Dr. Nearpass: Oh yes! Coca works amazing. It is a plant that grows in the high altitudes of South America and when I was living in Ecuador the folks that live in the Andes drink coca tea all the time. They also take coca leaves and shove a wad in their mouth like chew. While they are doing work, cardiovascular work, they just put it in their mouth and that is their medicine. It gives them more stamina and reduces fatigue. There is not much research on it because you cannot even get it in the states.

Is there a reason you can’t get it here?

Dr. Nearpass: Because it’s the same plant as cocaine. We used to have a homeopathic version of it. Do you know what homeopathic medicine is? You take a remedy and you dilute it until you don’t have any molecules of the original substance but you basically are getting an energetic imprint. For example, Rhus tox, poison ivy, the homeopathic rhus tox is used to treat red itchy inflamed poison ivy type symptoms. But with coca, even homeopathically, the herb is used in concentrated doses to treat high altitude sickness and increase energy and stamina. But because there is such a control over coca, we can’t even get the homeopathic version, which is ridiculous because there is not a single molecule of the plant in the remedy.

Dr. Pollack: When Kim and I were on our honeymoon, we passed through Bolivia and Peru. In Bolivia in la Paz there was a coca museum. It was really fascinating because something around 1,000lbs of coca leaves must be distilled down into 1 gram to make cocaine. When you make tea out of the raw leaves it seems to have the subtle effect of suppressing appetite and allowing people to do better at altitude. Marijuana has a whole stigma around it, even though it has been legalized, and so the research and researchers are stigmatized, yet there are a lot of useful compound coming out of the plant. So, I’m sure that coca is the same, and hopefully somewhere down the line we will be able to use coca leaf for altitude.

Dr. Nearpass: And certainly, coca is the number one herb in the Andes that people use. You can get it everywhere, it’s like black tea down there.

So because coca is not available for your patients, and if you found Acli-Mate was not successful, what would you recommend?

Dr. Nearpass, a woman in a white hoodie, long brunette hair, and a maroon mask, stands in front of a wall of shelves of naturopathic medicine in brown glass jars with black lids at the Backcountry Apothecary in Frisco, CO.
Dr. Kimberly Nearpass

Dr. Nearpass: This is the thing about naturopathic doctors, we look at each individual. If it’s a resident, per se, we are going to draw blood work. We are going to try to figure out what’s going on, what is the underlying issue. Do you have relative anemia? We will run iron but also ferritin. They may have normal blood cells, normal H&H but their ferritin is a 2. One of the things that is tricky about being a naturopathic doctor is, we will be at a party and someone will ask, “Well what do you do for hypertension?” or “What do you do for digestive issues?” We always say we don’t treat symptoms; we don’t treat disease, we treat people. If someone is having recurrent altitude sickness, we are going to look at the individual and look at what is going on. What’s their diet? Are they hydrated enough? Are they drinking too much alcohol? Do they have subclinical hypothyroidism that might affect their metabolism and their ability to adapt when they get here? Might their ferritin levels be really low? And then we would sit down with the patient and say, “Well what are your symptoms? Is nausea the main symptom? Is headache the main symptom?”  And then, what other factors could be contributing to these symptoms? If it’s headache then CoQ10 would be what I would go to.

Dr. Chris Ebert-Santos: And what do you look for on physical exams on residents that are having trouble with altitude?

Dr. Nearpass: On physical exams we are doing the standard physical that you would do but we are also looking at the tongue. I am not a Chinese Medicine doctor but the tongue does give you some insight on what is going on in the digestive tract. If we are seeing inflammation or glossitis or geographic tongue, we are thinking, “Oh, this person may have some underlying digestive issue.” We might look at Arroyo’s sign, it’s a traditional sign when you shine a light on someone’s pupil and most of the time their pupil will constrict, but Arroyo’s sign is both pupils will stay dilated. This is a red light for adrenal issues, for hyper cortisol output or adrenaline output. If someone is in a chronically stressed state, their pupils are going to be dilated all the time. If it looks like someone has chronic stress, it takes you out of the parasympathetic, and so their digestion is going to be weaker. The way we look at it is the body has to prioritize, and there is only so much that one body can do. And I suspect that living at high altitude puts chronic stress on the body. I see this huge lack of libido in the women. I see women in their 20s, 30s, 40s, 50s. But it kind of makes sense right? If the body is chronically stressed, having a baby is a huge energy output for a woman. So, I think we may see the chronic stress impacts of living at high altitude.

Dr. Chris Ebert-Santos: So what do you do for the libido?

Dr. Nearpass: That is one that if I could invent one pill, it would be that one. Libido is really hard, especially in women. Unfortunately, what I see is its one of the first things to go in women and it’s one of the last things to respond. So, my suspicion is that this altitude is another physical stress on our bodies. I think we can see multiple systems being affected by it, maybe not severely but still.

Rachel Mader PA-S: Is there anything for sleep at altitude? I know a lot of people struggle with that.

Dr. Nearpass: Yes, again for us there is no magic bullet. Melatonin is very well known and that can be very helpful for some people, but it sure doesn’t work for everybody.  When patients come in and say, “What do you use for sleep?” I want to take every person back and have a conversation with them. Ask, “Are you having a hard time falling asleep? Are you having a hard time staying asleep? Are you waking up to go to the bathroom?” Right? So, there isn’t a magic bullet that will work for everyone. Breaking it down, I think you could have 50 people with altitude sickness and we’re going to do 50 different things. I mean, I would start with Acli-Mate, but every patient will be different.

Do you think there’s benefit to adding Acli-Mate in combination with an Acetazolamide prescription?

Dr. Nearpass: As far as I know, there’s no issue combining the two. Most people that come to us are usually trying to avoid medication, but what I always say to them in that situation is, “Try this other stuff to see if it helps.” But if it’s someone who had trouble in the past with AMS, I’ll say go to your medical doctor and get the prescription so that you have it if you need it. I think another issue is that people fly here right from Texas. They fly to Denver, they get right on the shuttle, and they drive right up here. If they’ve had trouble in the past, they should drive here and take their time. Spend a couple days in Denver if they have to. That does seem to help people.

Thank you so much Dr. Nearpass. Is there anything else about naturopathic medicine and high altitude you would like to share with us?

Dr. Nearpass: I guess I would say again that from a naturopathic perspective it is really about looking at the individual.

Is there anything that could specifically help with nausea symptoms of AMS?

Dr. Nearpass: Ipecacuanha! Ipecac syrup — which in full doses will make you throw up, so the homeopathic Ipecacuanha we use for nausea — that is one I have actually used quite a bit for people who have that aspect of AMS. It is really good for nausea and pregnancy too.

PA student Hannah Addison with Dr. Pollock, Dr. Nearpass and Dr. Chris in front of the Naturopathic clinic and apothecary in Frisco, CO.

The way I see Healthcare is a full spectrum, and on one end you have the brain surgeons and on the other end you have the Reiki energy healers. Then you have everything in between. I see us sitting in the middle. For patients, the best thing is to be aware of where they belong on that spectrum. I’m not going to replace a brain surgeon, but sometimes a little bit of massage and energy can do the trick. It is so great for us as practitioners to be able to talk and converse with the medical doctors. We’ve been really lucky in this community.

Visit Mountain River Naturopathic Clinic’s website or stop by their shop and clinic: http://www.mountainriverclinic.com

Available research articles on Naturopathic Remedies and AMS:

Zhang DX, Zhang YK, Nie HJ, Zhang RJ, Cui JH, Cheng Y, Wang YH, Xiao ZH, Liu JY, Wang H. [Protective effects of new compound codonopsis tablets against acute mountain sickness]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 May;26(2):148-52. Chinese. PMID: 20684264.

Tsai TY, Wang SH, Lee YK, Su YC. Ginkgo biloba extract for prevention of acute mountain sickness: a systematic review and meta-analysis of randomized controlled trials. BMJ Open. 2018;8(8):e022005. Published 2018 Aug 17. doi:10.1136/bmjopen-2018-022005

Gertsch JH, Basnyat B, Johnson EW, Onopa J, Holck PS. Randomised, double blind, placebo-controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high-altitude illness trial (PHAIT). BMJ. 2004;328(7443):797. doi:10.1136/bmj.38043.501690.7C

Ke T, Wang J, Swenson ER, et al. Effect of acetazolamide and gingko biloba on the human pulmonary vascular response to an acute altitude ascent. High Alt Med Biol. 2013;14(2):162-167. doi:10.1089/ham.2012.1099

Wang J, Xiong X, Xing Y, et al. Chinese herbal medicine for acute mountain sickness: a systematic review of randomized controlled trials. Evid Based Complement Alternat Med. 2013;2013:732562. doi:10.1155/2013/732562

Lee SY, Li MH, Shi LS, Chu H, Ho CW, Chang TC. Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats. Evid Based Complement Alternat Med. 2013;2013:718739. doi:10.1155/2013/718739

Hannah Addison, PA-S

Hannah Addison (she, her, hers) is a second-year physician assistant student at Red Rocks Community College Physician Assistant Program in Arvada Colorado. Hannah was born and raised in the South Denver area of Colorado. She spent four years getting her bachelor’s in biomedical science at Colorado State University in Fort Collins, CO where she decided her life career goal was to become a PA. After graduating and while applying for PA programs, Hannah worked at Littleton Adventist Hospital of Centura as a CNA, Telemetry Technician and Unit Clerk. In her free time, Hannah enjoys hiking and discovering all the delicious food and drink Colorado has to offer.

COVID in the Mountains: What Works?

As the nation experiences its second, and by far more significant, increase in COVID-19 cases, visitors continue to flock to the Colorado Rocky Mountain region, while advisories from the CDC and government officials across the world continue urging people to stay isolated and home for the holidays. Unlike the Northern Mariana Islands or New Zealand, where physical distancing, the use of masks, travel bans and mandatory quarantines have allowed these island nations to maintain zero community spread, Colorado remains open to the potentially millions of travelers it sees every Winter season, and with far fewer mandates to control infection.

Although the beginning of the pandemic saw facilities managing to protect their staff with protective equipment and protocols, during this dramatic second wave of reported cases, we are seeing an increase in cases among essential health care workers. And with the regular flu season well underway, it seems more critical than ever that we do everything we can to limit exposure.

Ebert Family Clinic, in the heart of Summit County, Colorado, surrounded by world-class ski resorts drawing visitors from all over the world, has successfully managed to avoid infection among all its staff, in spite of continuing to serve its patient population since the initial lockdown this past March.

How?

“First of all, we kept our door locked. You can only come in one at a time, we meet you at the door, screen your temperature, ask if you have any symptoms; we screen when you make an appointment and make sure if anyone in your household is sick, you reschedule your appointment. If so, we made you a telehealth appointment,” says pediatrician and president Christine Ebert-Santos, MD, MPS.

And the telehealth appointments have been a success all year, saving a lot of travel and risk of exposure, making primary health care even more accessible.

Even now, Ebert Family Clinic’s pandemic protocol hasn’t changed. “But just as importantly, all of our employees are maintaining a bubble with close contacts,” adds Dr. Chris.

Operations weren’t always smooth: “Two times, when someone close to a staff member, like in our family, was sick, we stayed home,” says The Doc about having to close the clinic. I stayed home until [my husband’s] test was negative, [our nurse practitioner,] Tara stayed home until her husband’s test was negative; until we knew we didn’t have COVID. We based the risk of COVID on the standard that is described of having been within six feet of an infected person in a closed space.”

Is the vaccine going to change protocols?

“The vaccine isn’t going to change anything. The announcement from Public Health today tells exactly how many doses. That’s a drop in the bucket. What’s that when we have 30,000 residents and 90,000 visitors? It’s going to be six to nine months before we see any protection from this vaccine,” Dr. Chris confirms.

“Essential workers all have their protocols, and they’re just as important as ever. [If you can’t work] — all the parents who have to stay home with their kids, or the restaurant servers who are laid off — I’m hoping that the people who are doing well in our community can continue to help those who are suffering. There is a big sector of our community, like real estate or repairs or construction workers who have been able to continue working through this pandemic. I think [these people who are out of work] are getting help from the FIRC or applying for rent assistance. I haven’t had anyone say that they’re really struggling. And we conduct social welfare interviews, “Do you feel safe? Do you have food?” We’re doing anxiety and depression screenings on everybody. And there is a high level of anxiety among all ages. 

“We had a meeting with Heart-Centered Counseling, and now we’re plugged in with them. We have their brochures, and we’ve just signed care coordination to connect people with providers [who can help in this situation].”

Dr. Chris encourages everyone in the community to reach out with their needs. Ebert Family Clinic and other health care institutions have done very well maintaining a cohesive network of resources for everyone in search of financial, physical, mental, and emotional assistance.

Feel free to inquire about appointments or referrals to local resources at info@ebertfamilyclinic.com, or call the clinic at (970) 668-1616.

Dr. Chris with her granddaughter, comfy-cozy.

“Everybody enjoy their Christmas Zoom with their relatives. As for us, we are having a small family Christmas with six of us who work and live together, and we’re all wearing hoodie-footie flannel jammies.”

Happy Holidays from Dr. Chris, Ebert Family Clinic, and highaltitudehealth.com!

robert-ebert-santos

Roberto Santos is from the remote island of Saipan, in the Commonwealth of the Northern Mariana Islands. He has since lived in Japan and the Hawaiian Islands, and has made Colorado his current home, where he is a web developer, musician, avid outdoorsman and prolific reader. When he is not developing applications and graphics, you can find him performing with the Denver Philharmonic Orchestra, snowboarding Vail or Keystone, soaking in hot springs, or reading non-fiction at a brewery.

Your Baby or Child Is On Oxygen

This is a handout distributed by Dr. Christine Ebert-Santos, MD, MPS, at Ebert Family Clinic, Frisco, Colorado.

Living at high altitude is a challenge for our bodies. The amount of oxygen in the air we breathe is less the higher you go. Since we all need oxygen to live, this can cause problems.

There are three times when oxygen may be needed by children living at altitude:

  1. During the newborn period;
  2. When a child has a respiratory illness, even a mild cold;
  3. During the first 48 hours after returning/arriving from sea level.

When a baby takes their first breath, the higher oxygen level in the air sets off many changes in the heart, lungs and blood vessels around the lungs that convert the child’s respiratory system from transferring oxygen from the placenta to the lungs. Exposure to a low oxygen environment during the first few weeks can interfere with the normal fall in the pressures of the blood vessels in the lungs and closing of the vessels that shunted blood away from the lungs in the womb.

In babies and children, we are not worried about brain damage from lack of oxygen due to the altitude. Don’t panic if the oxygen cannula falls off during the night or the tank runs out. The problems caused by the low oxygen saturations (usually running between 78 – 88%) seen at altitude develop over days, weeks or years, due to changes in the heart and lung. Hypoxia, the term for low oxygen in the blood, causes constriction, or narrowing, of the blood vessels in the lungs. This can lead to back pressure on the lungs and heart, which may cause fluid to leak into the air sacs in the short term or abnormal increases in the heart muscle in the long ter.

Rarely do babies or children with low oxygen levels at altitude show symptoms. The normal oxygen saturation levels at 9000′ are about 92 – 93%, and can be 89 – 90% in healthy people. We start treating with oxygen below 89%, even though symptoms like trouble breathing, fast breathing, poor sleep, or poor color are unusual until the saturation level is in the 70’s.

It is important to understand that oxygen is prescribed by your doctor to treat symptoms of altitude sickness such as headache, vomiting and trouble breathing, and to prevent more severe symptoms from developing. A small percent of persons with mildly low oxygen levels will suddenly, over a few hours, go into full-blown pulmonary edema where their lungs fill with fluid, they have much more trouble breathing, and turn blue. This is a life threatening emergency.

When you arrive home with your child on oxygen, be sure and call the respiratory therapist at the phone number on the tank so they can come to your house and teach you about the equipment. Don’t feel discouraged if your toddler or young child is fighting the oxygen at first. They will usually adjust and accept the cannula in about 30 minutes.

Acetazolamide

Typical symptoms of acute mountain sickness (AMS) are headache, loss of appetite, disturbed sleep, nausea, vomiting, fatigue, and dizziness. However, more serious conditions such as high altitude pulmonary edema (HAPE) or cerebral edema (HACE) can present with this illness. Avoiding these unpleasant symptoms while at elevatione is possible through gradual pre-acclimatization when possible (what science recommends!), or there are specific medications that can potentially prevent the development of AMS, such as acetazolamide. This article will address how acetazolamide (also known as Diamox) can help prevent AMS, discuss the physiological effects of the medication, some side effects, and whether or not this drug can enhance physical performance.

 How does it work?

Acetazolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase regulates kidney absorption of sodium bicarb and chloride. Acetazolamide works by inhibiting carbonic anhydrase, preventing the reabsorption of sodium bicarb and chloride, causing acidosis in the blood. When experiencing AMS, the body is in a state of respiratory alkalosis. By taking acetazolamide, which causes metabolic acidosis it drives receptors in the body to increase the patient’s minute ventilation by as much as 50%, improving arterial PO2 and increasing oxygen saturation.

How can I obtain acetazolamide and when should I start taking it?

Acetazolamide requires a doctor’s prescription, and the typical dose for the prevention of AMS is 125 mg twice daily. The typical recommendation is to start taking acetazolamide one day before your exposure to high altitude and continue usage throughout your trip. When taken one day before exposure, studies show that acetazolamide reduced AMS incidence and enhanced tolerance to submaximal exercise on the first day at high altitude versus starting administration the day of arrival.2 However, if, for some reason, the medication isn’t started a day before arrival to high altitude, then the medication should be started upon arrival, which still shows a decreased incidence in the development of AMS. 

Allergies & Side Effects

Acetazolamide belongs to a classification of drugs known as sulfonamides, which is broken down further into two categories: antibiotics and nonantibiotics. Acetazolamide is considered a nonantibiotic sulfonamide, which varies significantly from sulfonamide antibiotics because these antibiotics contain what is known as an arylamine group in their chemical structure. This arylamine group is a key component of the allergic response to sulfonamide antibiotics (sulfamethoxazole, sulfasalazine, sulfadiazine, and the anti-retrovirals amprenavir and fosamprenavir); however, this structure is not present in other sulfonamide drugs like acetazolamide.1 There is available evidence that suggests patients who are allergic to arylamine sulfonamides do not cross-react to sulfonamides that lack the arylamine group and so may safely take non-arylamine sulfonamides.1 Patients with known allergies to sulfonamide drugs should consult with their healthcare provider before taking acetazolamide.

Like all other medications, there are risks that side effects will occur with acetazolamide’s administration. The common side effects are fatigue, malaise, changes in taste, paresthesia, diarrhea, electrolyte disorders, polyuria, and tinnitus. While conducting research, I found 3 – 4 people from my hometown, located at 69 feet above sea level, who have taken acetazolamide while rapidly ascending to 8,000+ feet to ski or hunt. When asked how their experience was taking acetazolamide, the common response was that they stopped using it within the first two days due to the change in the taste of their beer! The pleasurable “fizz” in our carbonated drinks is attributed to chemical excitation of nociceptors in the oral cavity via the conversion of CO2 to the carbonic acid in a reaction catalyzed by carbonic anhydrase. So administering a carbonic anhydrase inhibitor like acetazolamide results in flat-tasting carbonated drinks, or, as described by the aforementioned subjects, a “nasty beer”!4 While a bad tasting beer is no fun, AMS is a lot less fun, and one would be best advised to continue taking acetazolamide while at high altitude.

Can taking acetazolamide increase physical performance and endurance at high altitudes?

Though enticing, it doesn’t seem to work out that way. There are multiple studies on exercise endurance in hypoxic conditions with the administration of acetazolamide, but the produced results are confounding. The majority of the studies show that for a non-acclimated person taking acetazolamide in hypoxic conditions, endurance and exhaustion time were increased with submaximal and maximal exercise. A few reasons this may be true are the induction of metabolic acidosis and its effects on muscle cells, the diuretic effect of the drug inducing dehydration, and additional increases in work of breathing cause vasoconstriction in locomotor muscles, which can impair exercise performance.3 Regardless, this medication’s proven science in the prevention of AMS should not be mistaken with the multiple confounding studies on exercise endurance.

Scott “Scotty B” Rogers, FNP-S

From Opelousas, Louisiana, Scott Rogers is currently a Family Nurse Practitioner student at Walden University after having practiced five years as an RN following his BSN from the University of Louisiana at Lafayette. He has lived in Colorado for the past four years where he enjoys hiking with his wife and dog, snowboarding all the resorts in Summit County, and basketball, and hopes to pursue more work with acute physical rehabilitation, orthopedics, and sports medicine.

References

1. American Academy of Allergy Asthma & Immunology. (2019, June 23). Acetazolamide and sulfonamide allergy: AAAAI. Retrieved November 13, 2020, from https://www.aaaai.org/ask-the-expert/acetazolamide

2. Burtscher, M., Gatterer, H., Faulhaber, M., & Burtscher, J. (2014). Acetazolamide pre-treatment before ascending to high altitudes: when to start?. International journal of clinical and experimental medicine, 7(11), 4378–4383.

3. Garske, L., Medicine, 1., Brown, M., Morrison, S., Y, B., G., B., . . . Zoll, J. (2003, March 01). Acetazolamide reduces exercise capacity and increases leg fatigue under hypoxic conditions. Retrieved November 13, 2020, from https://journals.physiology.org/doi/full/10.1152/japplphysiol.00746.2001

4. Jean-Marc Dessirier, Christopher T. Simons, Mirela Iodi Carstens, Michael O’Mahony, E. Carstens, Psychophysical and Neurobiological Evidence that the Oral Sensation Elicited by Carbonated Water is of Chemogenic Origin, Chemical Senses, Volume 25, Issue 3, June 2000, Pages 277–284, https://doi.org/10.1093/chemse/25.3.277

A conversation with Dr. Chris on neonatal oxygen levels at elevations 9000’ and above

My name is Austin Ethridge, I am a physician assistant student from Red Rocks Community College PA program who has been fortunate enough to have completed my pediatric rotation with Dr. Chris in Frisco, Colorado, this month. Dr. Chris has extensive experience providing care to the pediatric residents of Summit County, having established her practice here in 2000, following 20 years as a pediatrician on Saipan, in the Northern Mariana Islands, southeast of Japan. She has a unique perspective on high altitude health, having transitioned from sea level to the 8000′ and above elevations unique to Summit County. Since moving here, she has been advocating for more in-depth medical research regarding the needs specific to these high-altitude communities. We are here in her office today at the Ebert Family Clinic to discuss neonatal oxygen use in Summit County.

Dr. Chris, based on your experience, why do neonates need oxygen at a higher elevation? Is it because they need to acclimate?

Yes, that’s basically it, and smaller lung size at birth.

Yes, that’s what I read. Basically, the maternal physiology compensates for the higher altitude. When the infant is born, their lung size and physiology need to catch up to the altitude.

Based on your practice, when do you place neonates on oxygen?

Usually at 89% or below, but you see, that’s just it. Many parents ask why their children need to be on oxygen when neither themselves nor their siblings were on oxygen. One of the primary reasons that this has become more of an issue is the less invasive methods of measuring oxygen saturation in the blood. Before the 1990s, the only time to measure oxygen saturation in a newborn was if a concern for illness or pulmonary problems existed, which was completed by obtaining an arterial blood gas, a very invasive procedure. Do you know at what oxygen saturation level we begin to detect cyanosis in neonates?

Around75%, which means before the pulse oximeter used today, we had no idea if the infant’s oxygen saturation was in the 80s! Now that we have the pulse oximeter, we have access to so much more information. And this is why it is essential to determine the normal oxygen levels for these infants at higher elevations.

Does this include cyanosis or blue discoloration of the hands and feet, or is it just central as in the face and chest?

The blue discoloration of legs and arms do not count; this is very common and not concerning, only the discoloration of the trunk and face.

Yes, based on the articles that I have been reading while I have been here, there are not many studies that reflect normal oxygen saturation in neonates at a higher elevation. Most of the articles that I did find determined that newborn oxygen saturation is lower at elevations of around 6000’, with average values within the range of 89-96% SpO2 compared to greater than 97% at sea level. However, there could be a significant difference between 9000’-10000’ feet and the 6000’ in these studies.1-3

That is exactly right, and that is why I want to do a study here in Summit County to determine the average oxygen saturation at these altitudes.

On average, how many newborns do you place on oxygen in Summit County?

About 40% of newborns are placed on oxygen due to low oxygen levels at birth, and I would say that less than 5% will still need oxygen after their two-week visit; however, this rate may be higher in those that live at elevations of 10,000′ or greater. In general, studies have observed that the lowest oxygen levels tend to occur around the 4th day of life and then improve from this point onward. What is the main complication that we are worried about in infants that have low oxygen levels?

Pulmonary hypertension. At birth, when the fetal circulation is shunted back through the lungs, the pulmonary pressure decreases to allow this to happen. If the oxygen levels are too low, the vessels in the lungs may not dilate enough, and this could lead to elevated pulmonary pressures. I read an interesting study that found increased pulmonary pressures in Tibet children as measured by ECHO cardiogram until the age of 14. These pressures were noted to increase with increasing elevation but to decrease with increasing age. Generally, by the age of 14, the pulmonary pressures had normalized; the authors considered this to be a normal physiological response. However, it is worth noting that these children in the study came from generations of individuals that have always lived at these altitudes.4-5

That is correct. That is the difference between adaptation and acclimatization. Many of the children that live up here are acclimatized, meaning that their bodies have adapted on a physiological level, but their genetics remain the same. However, adaptation is observed in many families that have lived at high elevations for generations; in these instances, the changes have occurred at the genetic level.

That makes sense; so the data from some of those studies may not directly apply to the population here.

That is correct. Are we worried about brain damage in this setting of low blood oxygen levels?

No, I do not think so.

We are not! In fact, as an example of this: when I was in Saipan, there was a child that had a cyanotic, congenital heart defect that was unable to be repaired for social reasons. This child always appeared blue, and his oxygen saturation would have been very low. He did just fine in terms of development and progress in academics. There were no signs of developmental delay or any other neurological problems at all.

Are there any resources you recommend for parents whose newborn may need to be on oxygen?

Yes, I have a handout that I provide to all families whose infants are on oxygen. (View Dr. Chris’s handout here.)

Are there any red flags or signs that the newborns’ oxygen may not be high enough when they are sent home? Is there anything parents should look out for? I know that you mentioned the oxygen level needs to be as low as 75% before there are any signs of concerning central cyanosis.

No, there really are no clinical signs. A company called Owlet produces a sock for the newborn’s foot that monitors oxygen saturation. I am not sure how accurate this is, but if the parents really want to do something to monitor the oxygen level, this could be a way to do so. It is pretty expensive. On an aside, we are currently in communication with this company regarding future opportunities to conduct research using their product with regards to newborn oxygen saturation at higher elevations, so stay tuned for more developments on this topic.

Are there any risks to starting the infant on oxygen?

No, not at the level that these newborns are sent home on. In premature infants, there is a risk associated with oxygen therapy for eye and lung disease. However, these premature infants are placed on very high flow rates and positive pressures. The damage is actually caused by the pressures of the oxygen being too high. This is not the case for the newborns that we place on oxygen.

Are there any risks to infants or children growing up at high altitude?

Yes, there is some evidence of a very slight increased risk of pulmonary hypertension, but this is very rare.

Thank you so much for taking the time to discuss this, Dr. Chris!

References

  1. Ravert P, Detwiler TL, Dickinson JK. Mean oxygen saturation in well neonates at altitudes between 4498 and 8150 feet. Adv Neonatal Care. 2011 Dec;11(6):412-7. doi: 10.1097/ANC.0b013e3182389348. Erratum in: Adv Neonatal Care. 2012 Feb;12(1):27. PMID: 22123474.
  2. Morgan MC, Maina B, Waiyego M, Mutinda C, Aluvaala J, Maina M, English M. Oxygen saturation ranges for healthy newborns within 24 hours at 1800 m. Arch Dis Child Fetal Neonatal Ed. 2017 May;102(3):F266-F268. doi: 10.1136/archdischild-2016-311813. Epub 2017 Feb 2. PMID: 28154110; PMCID: PMC5474098.
  3. Bakr AF & Habib HS, Normal Values of Pulse Oximetry in Natewborns at High Altitude. Journal of Tropical Pediatrics 2005; 51(3) 170-173.
  4. Qi HY, Ma RY, Jiang LX, et al. Anatomical and hemodynamic evaluations of the heart and pulmonary arterial pressure in healthy children residing at high altitude in China. Int J Cardiol Heart Vasc. 2014;7:158-164. Published 2014 Nov 12. doi:10.1016/j.ijcha.2014.10.015
  5. Remien K, Majmundar SH. Physiology, Fetal Circulation. [Updated 2020 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539710/
  6. Thilo EH, Park-Moore B, Berman ER, Carson BS. Oxygen Saturation by Pulse Oximetry in Healthy Infants at an Altitude of 1610 m (5280 ft): What Is Normal? Am J Dis Child. 1991;145(10):1137–1140. doi:10.1001/archpedi.1991.02160100069025

Austin Ethridge is a second-year physician assistant student at the Red Rocks Community College Physician Assistant Program. Originally from the Colorado front range, Austin attended the University of Northern Colorado where he obtained both a bachelors and masters degree in chemistry prior to attending PA school. In his free time, Austin enjoys spending time with his friends and family, reading, and cycling.

WMS Blog Entry No. 5: Advances in Frostbite, a Synopsis of Dr. Peter Hackett’s Lecture

Frostbite is an injury caused by freezing of the skin and underlying tissue. The main pathophysiology of frostbite is ischemia. Basically, where there is blood flow there is heat and where there is no blood flow there is no heat to that area. The vasoconstriction and loss of blood flow to the skin predispose the skin to becoming frozen. Heat transfer depends on blood flow and blood flow depends on sympathetic nerve tone. In our extremities, there are only nerves that cause vasoconstriction. Exposure to cold or a drop in the body’s core temperature can induce vasoconstriction from these sympathetic nerves in which decreases the amount of blood flow to the extremities to keep the central aspect of the body warm and central organs well-perfused to help to maintain the body’s core temperature.

Frostbite usually occurs in the apical areas of the skin also called glabrous, which is Latin for smooth because these areas have no hair. These areas include the face, palmar surface of the hand, and the plantar surface of the foot. These areas of the skin are rich in arteriovenous anastomoses, which are low-resistance connections between the small arteries and small veins that supply the peripheral blood flow in the apical regions of the skin. These anastomoses allow the blood to flow into the venous plexus of the skin without passing through capillaries, and play a major role in temperature regulation.

Causative factors of frostbite include inadequate insulation, circulatory compromise, dehydration, moisture, trauma, and immobility. All of these factors in combination can result in frostbite.

The behavioral risk factors include mental illness, alcohol/drug use, fear, apathy, and anxiety. All of these risk factors can contribute to frostbite, generally, from poor self-care.

Frostbite is said to kill twice during its two phases that occur. The first phase is the frozen phase in which ice crystals form in the intracellular compartment at about 29 degrees Fahrenheit. These ice crystals will suck the fluid out of the endothelial cells and become enlarged causing the endothelial cells to lyse from dehydration and interrupt microcirculation. The second phase is the rewarming phase in which the skin thaws and is at risk for microthrombi production and necrosis due to prolonged injury to those endothelial cells.

The usual phase at which we see frostbite in a clinical setting is after thawing, in which the skin looks flushed pink, red, with the appearance of blebs that form one hour to twenty-four hours after thawing. These blebs can rupture spontaneously in 4-10 days and shortly after, a cast-like eschar forms. Then the eschar usually sheds in 21-30 days.

Deep Frostbite

Frostbite is classified based on the depth of tissue damage, from superficial with no tissue damage being mild and deep tissue damage including muscle, bone, or tendon being classified as severe frostbite. The mildest form of frostbite is called frostnip. Frostnip is freezing of the skin but there is no actual freezing injury and doesn’t cause permanent skin damage.

Stages of Frostbite

What can you do in the field for Frostbite?

It is important to provide supportive care with IV or PO hydration to prevent dehydration. If the affected area is frozen with no imminent rescue, it is recommended to thaw the area with warm water and try to avoid refreezing. You can give NSAIDs, such as Ibuprofen, 400 mg every 8 hours, or ketorolac 30 mg IV. If the person is at altitude and their oxygen saturation is low you can provide oxygen. However, the individual must be taken to the nearest hospital for further treatment, especially in cases of severe frostbite.

New research studies have been exploring the use of thrombolytics in the treatment of frostbite. Many of the research studies have shown that IV TPA or iloprost may be of benefit to administer in a hospital setting. However, iloprost is not approved for IV use in the United States and other prostacyclins have not been studied for the use of frostbite as of yet. There are current literature and guidelines that have been published for the prevention and treatment of frostbite, however, more research is needed to further support standardized treatment of all patients with frostbite with thrombolytic therapy. Hopefully, these new studies will encourage more research into using thrombolytics and prostacyclins for frostbite.

In the meantime, it would be best to stay warm to prevent frostbite. Tips to help in frostbite prevention include:

  • Limit time you’re outdoors in cold, wet, or windy weather. Pay attention to weather forecasts and wind chill readings. In very cold, windy weather, exposed skin can develop frostbite in a matter of minutes.
  • Dress in several layers of loose, warm clothing. Air trapped between the layers of clothing acts as insulation against the cold. Wear windproof and waterproof outer garments to protect against wind, snow, and rain. Choose undergarments that wick moisture away from your skin. Change out of wet clothing — particularly gloves, hats, and socks — as soon as possible.
  • Wear a hat or headband that fully covers your ears. Heavy woolen or windproof materials make the best headwear for cold protection.
  • Wear socks and sock liners that fit well, provide insulation, and avoid moisture. You might also try hand and foot warmers. Be sure the foot warmers don’t make your boots too tight, restricting blood flow.
  • Watch for signs of frostbite. Early signs of frostbite include red or pale skin, prickling, and numbness.
  • Eat well-balanced meals and stay hydrated. Doing this even before you go out in the cold will help you stay warm.

Lauren Pincomb Apodaca is a second-year Physician Assistant student in the Red Rocks Community College Physician Assistant Program. Originally from Las Cruces, New Mexico, she graduated from New Mexico State University with a Bachelor of Science in Biochemistry and a Bachelor of Art in Chemistry. After obtaining her undergraduate degrees, she was accepted as a Ph.D. fellow in Pharmacology at the University of Minnesota where she conducted research in a biomedical laboratory doing cancer research. She then realized that she wanted to make a difference in people’s lives through hands-on experience rather than working in a laboratory. She went back to New Mexico and received her certification as a nursing assistant and started from the ground up to reach her ultimate goal of being a Physician Assistant. She has enjoyed living in Colorado and the many outdoor activities that Colorado has to offer. Her favorite are kayaking, fishing, and hiking. She is looking forward to graduating soon.

References:

Hill, C. (2017, December 22). Cutaneous Circulation – Arteriovenous Anastomoses. Retrieved September 27, 2020, from https://teachmephysiology.com/cardiovascular-system/special-circulations/cutaneous-circulation/

Frostbite. (2019, March 20). Retrieved September 27, 2020, from https://www.mayoclinic.org/diseases-conditions/frostbite/symptoms-causes/syc-20372656

WMS Blog Entry No. 4, Part I: Tick Bite Prevention and Proper Removal

Ticks are blood feeding parasites. Ticks are known as vectors because they can transmit different pathogens responsible for several diseases including Colorado Tick Fever, Rocky Mountain Spotted Fever (RMSF), Tularemia and relapsing fever. While there are 27 species of ticks in Colorado, almost all human encounters w/ ticks in Colorado involve the Rocky Mountain wood tick, a tick that only lives in the western U.S. and southern Canada at elevations between 4,000 and 10,000 feet. Another highly prevalent tick is the brown dog tick which is specific to dogs.

Before you go out!

DO:

  • Wear protective clothing! Wearing long sleeved shirts, long pants tucked into your socks and close toed shoes can keep ticks from getting onto your skin, as ticks are usually acquired while brushing against low vegetation.
    • wear light colored clothing, as this makes it easier to find ticks that have been picked up
    • Treat clothing w/ permethrin as this can help kill or repel ticks for days to weeks! Do not apply directly to skin.
  • Use Tick repellent. This includes the well-known DEET along with picaridin, IR3535 and oil of lemon eucalyptus
    • Repellent can be applied either directly to skin or to clothing, AND is most effective if applied to the lower body that is likely to come in contact with ticks first!
    • If applying repellents to skin:
      • DO NOT use high concentration formulas on children (DEET concentration > 30)
      • AVOID applying repellents to your hands or other areas that may come in contact with your mouth
      • DO NOT put repellent on wounds
      • ALWAYS wash skin that has had repellent on it.
  • Remember: Dogs can get ticks too! Don’t forget to consult your veterinarian about how to protect your furry friends against ticks.

When you go out: DO NOT assume that you won’t get bit.

  • Avoid tick habitat
    • Ticks are most active in spring and early summer and are concentrated where animal hosts most commonly travel, including areas of brush along field and woodland edges or commonly traveled animal host paths though grassy areas.
      • DO try to avoid exposure in these areas by staying in the center of marked trails when hiking to avoid brushing vegetation that ticks may be perched on waiting for you!
    • If possible, avoid these sites during tick season.
    • If you live in known tick territory, you may even get a tick bite in your own backyard! Decrease this risk by creating a tick-free zone around your house by keeping your lawn mowed, eliminating rodent habitats (wood or rock piles) around your house, and placing wood chips between your lawn and tall grasses or woods.

After coming back inside

  • Perform a tick check which includes botha visual and physical inspection of your entire body, as well as your gear and pets. Because ticks take several hours to settle and begin feeding, you have time to detect and remove them. You tend to not feel ticks because their saliva has histamine suppression and analgesic effects. Ticks like warm, moist and dark areas but can latch anywhere.
    • Examine your scalp, ears, underarms, in and around the belly button, around the waist, groin/pubic area, buttocks and behind your knees.
    • If camping, perform tick checks daily on humans AND pets, making sure to examine children at least twice daily. Again, pay special attention to the head and neck and don’t forget to check clothing for crawling ticks.
    • Shower and wash your clothes after returning home from the outdoors.

If you or a family member get bit by a tick: DO NOT PANIC, and DO NOT immediately rush to the emergency room! If the tick has been attached for less than a day, the chance of the tick transmitting one of these diseases is low. Removing ticks can be tricky, as they use their mouthparts to firmly attach to the skin.

Best method for tick removal -> remove as quickly as possible!

1. Grasp the tick with fine tipped tweezers as close to the skin as possible. If tweezers are not available, use a rubber gloved hand or place tissue or thin plastic over the tick before removing it to avoid possible transmission of disease.

2. Pull tick SLOWLY and with STEADY PRESSURE STRAIGHT away from the skin

  • DO NOT:
    • Crush, puncture, twist or jerk the tick as you remove it. This may increase risk of the tick regurgitating infected body fluids into the skin or leaving mouthparts in skin

3. After the tick is removed, disinfectant the attachment site on skin and WASH YOUR HANDS. Dispose of the live tick by placing in a sealed bag/container and submersing it in alcohol, then wrapping it tightly and crushing it in duct tape, OR flushing it down the toilet.

  • DO NOT:
    • crush the tick in your fingers
    • try to suffocate the tick still on the person by covering it with petroleum jelly OR touching it with a hot match to suffocate -> these methods can cause the tick to burst and INCREASE time the tick is attached, as well as making the tick more difficult to grasp

Remember: the goal is to remove the tick quickly from the host as opposed to waiting for it to detach on its own.

If you remove the tick and are worried, you can always put the tick in a sealed container with alcohol and bring the dead tick to your medical provider.

If you develop a rash or flu-like symptoms (fever, fatigue, body aches, headache) within several weeks of removing tick, see your medical provider and tell him/her about the recent tick bite, when it occurred and where you acquired the tick.

Remember: These diseases are very treatable if caught early enough!

Graphic taken from https://www.cdc.gov/ticks/pdfs/FS_TickBite-508.pdf

Stay tuned for next month’s explanation of the tick life cycle and tick-borne diseases in the high country!

References

1. Colorado Tick and Tick Born Diseases fact sheet. https://extension.colostate.edu/topic-areas/insects/colorado-ticks-and-tick-borne-diseases-5-593/ Accessed on 8/8/20

2. Peterson J., Robinson Howe. P. Lyme Disease: An Uptick in Cases for 2017. Wilderness Medicine Magazine: https://www.wms.org/magazine/1213/Lyme-Disease. Accessed 8/8/20

3. Do’s and Don’t’s of Tick Time: https://awls.org/wilderness-medicine-case-studies/dos-and-donts-of-tick-time/ Accessed 8/8/20

Laurie Pinkerton is a 3rd year Physician Assistant Student studying at Drexel University in Philadelphia, PA. Originally from Northern, VA, she graduated from the University of Mary Washington in Fredericksburg, VA with a degree in Biology in 2014. She moved to Keystone to live that ski life and stayed for 2 years, working as a pharmacy tech at Prescription Alternatives and as a medical assistant at Summit Cardiology. Prior to starting PA school, she moved to Idaho where she learned about organic farming and alternative medicine.  She has loved every second of being back in Summit County and learning here at Ebert Family Practice. She looks forward to practicing Integrative Medicine in the near future.

WMS Blog entry No. 1: The Rule of 3’s and other pearls from the annual Wilderness Medical Society Conference 2020

Over 800 participants from 25 countries joined the virtual conference this year which included Dr. Chris’ poster presentation on growth at altitude. Over the next several months we will extract the most relevant information to publish in our blog, starting with:

The Rule of 3’s

You can survive 3 minutes without oxygen

                              3 hours without shelter in a harsh environment

                              3 days without water

                              3 weeks without food

Dr. Christine Ebert-Santos presents her research on growth in children at high altitude, “Colorado Kids are Smaller.”

We will be sharing some of the science, experience and wisdom from these meetings addressing how to survive. For example, Dr. Peter Hackett of the Hypoxia Institute reviewed studies on how to acclimatize before travel or competition in a low oxygen environment.

Susanne Spano, an emergency room doctor and long distance backpacker discusses gear, how to build an emergency shelter in the wild, and when it is OK to drink from that refreshing mountain stream.

Michael Caudell presenting on plant toxicity.

Michael Caudill, MD shares what NOT to eat when you are stranded in the wilderness in his lecture on toxic plants.

Presentations included studies of blood pressure in people traveling from sea level to high altitude, drones delivering water to stranded hikers, an astronaut describing life and work at 400,000 m, what is the best hydration for ultra athletes, how ticks can cause meat allergy, and, as always, the many uses for duct tape.

Duct tape for survival.

We will also update you on the treatment of frostbite as well as a discussion about “Climate change and human health.”

Sign up for our regular blog updates so you can be updated on wilderness and mountain medicine!

COVID in Colorado Update: Reasons high altitude residents may be less susceptible

Last week we were privileged to have a Zoom discussion with two high altitude experts from the Instituto Pulmonar Y Patologia de la Altura (IPPA) founded in La Paz,  Bolivia in 1970. Dr Gustavo Zubieta-Calleja and Dr. Natalia Zubieta-DeUrioste answered our questions about their recently published article, Does the Pathogenesis of SAR-CoV-2 Virus Decrease at High Altitude?. They and the seven  coauthors presented data comparing COVID cases in high altitude areas of China, Bolivia and Ecuador showing a marked reduction in numbers compared to low altitude areas in the same countries, with dramatic, colorful topographic maps.

Drs. Zubieta-Calleja and Zubieta-DeUrioste and their colleagues theorized four reasons why altitudes above 2500 m could reduce the severity of the corona virus. (Note: Frisco, CO is at 2800 m, Vail 2500 m). As described in their previous paper published in March, the intense UV radiation at altitude as well as the dry environment likely reduce the viability of the virus in the air and on surfaces.

Dr. Zubieta-Calleja on a Zoom chat with Dr. Chris explaining a chart comparing UV exposure in La Paz, Bolivia (top line) and Copenhagen, Denmark (bottom line).
Dr. Chris with Dr. Gustavo Zubieta-Calleja and other altitude experts from the Hypoxia Conference in La Paz on the Camino Chacaltaya, which reaches an elevation of 17,785’/5421 m.

The low barometric pressure causes air particles to be spaced more widely, which would also decrease the viral particles inspired with each breath, reducing the severity and frequency of infections.

Furthermore, residents accustomed to chronic hypoxia may express reduced levels of angiotensin converting enzyme 2 (ACE2) in their lungs and other tissues. This enzyme has been found to be the entry path for the corona virus into cells where it replicates. Finally, the normal adaptation and acclimatization of populations with prolonged residence above 2500 meters may reduce the severity of the disease in individuals, and reduce mortality. This includes increased ventilation, improved arterial oxygen transport, and higher tissue oxygenation mediated by increased red blood cells produced under the influence of erythropoietin, which could be explored as a possible therapy.

Dr. Zubieta-Calleja with statistics reflecting the number of COVID-19 infections at different elevations in Bolivia. Note the most infections occur at a lower elevation.

As we stated in our interview quoted in the Summit Daily News March 17th, none of these factors can be relied upon to protect every individual. Therefore it is important to continue frequent hand washing, wearing masks, social distancing, and avoid touching your face.

COVID-19 Update: Accordion Theory and Preparing for Next Steps

Today, I am going to share news gleaned from meetings and publications that address the importance of preventive care, returning to daycare, pulse oximetry as a screening tool for COVID, and the Accordion Theory.

Every Thursday the Children’s Hospital of Colorado presents a panel of experts with updates and answers to questions.

“Your offices are the safest place in the country,” they proclaimed. With social distancing many parents and patients are delaying routine care which has led to the largest drop in vaccination rates in 50 years. This could result in outbreaks of measles, whooping cough, pneumococcal and other infections. With the loss of revenue, small clinics may go out of business, and large clinics and hospitals are laying off workers by the hundreds. If there is a large outbreak of preventable disease, on top of a resurgence of COVID, there could be a devastating shortage of providers to care for the victims. Now is the time to call your clinic and set up appointments for check ups and vaccines. If you don’t feel safe yet you can do a Telehealth visit initially and schedule the vaccines and hands-on portion of the exam in a month.

Another reason not to delay preventive care is the increase in stress, isolation, and anxiety which can cause serious depression. We had a tragic teen suicide in the county this month. Students from middle school through college should be seen annually for mental and physical health screening as well as vaccines. One mother told me that the depression screening done at our office “saved my daughter’s life.”

More daycares are opening soon. Parents are asking me whether to send their child back. These facilities follow strict public health guidelines to prevent infection. Children are not likely to be affected by COVID. Any child with symptoms should be tested. Enrollment should be diminished due to parents preferring to keep their child at home.  However, if there is a high risk family member, I advise not to return to daycare yet.

School age children should be limited to playing with friends and family members who have been part of their social circle during the last two months. To borrow a slogan from the AIDS campaign, “KNOW YOUR NETWORK”.  This is not the time to expand friendships. There will be no team sports this summer. Children should play outside and not share toys or balls.

An emergency physician in New York, Richard Levitan, published an editorial in the NY Times on April 20 advocating the use of pulse oximeters to screen for COVID. Citing the many patients with low oxygen levels and abnormal x-rays who did not complain of trouble breathing, the delay in obtaining results and inaccuracy of the COVID testing, he sees the simple pulse oximeter as a source of immediate information as to who needs medical attention. I’ve been speaking and writing about this for weeks.

Finally, one of the panelists at Children’s mentioned the accordion phenomenon. As we reduce social distancing restrictions and open commerce and travel, there will inevitably be more cases of COVID. It is likely that restrictions will be imposed again, and this may occur in cycles during the next year(s). We may be able to decrease future shutdowns by wearing masks and gloves when we go out, using hand sanitizer, soap and water, not touching our face, covering our coughs and sneezes, and limiting exposure to large groups of people. I hope all these will be permanent behavior changes except the masks and the large groups (I love the Lake Dillon Amphitheater and the BBQ challenge).

Take care, stay engaged, and have another safe week!