Accessibility, Acclimation, Altitude Science, Athletic Training, Child Growth & Development, Exposure, Genetics, Health, High Altitude, Medicine, Postural Orthostatic Tachycardia Syndrome (POTS)

Thin Air Making You Lightheaded?

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by Joy Plutowski, PA-S2

Feeling lightheaded after going to a high altitude is a key symptom of acute mountain sickness (AMS)—a condition caused by the reduced oxygen available in thin mountain air. AMS often comes with other symptoms like headache, nausea, and fatigue, usually starting after a recent climb to higher elevations.

But what if it’s not just AMS? For people with conditions like postural orthostatic tachycardia syndrome (POTS), which affects blood flow and heart rate, lightheadedness at altitude could be a clue to an underlying issue. While AMS happens because of low oxygen, POTS is tied to a problem with how the nervous system regulates the body. In some cases, going to altitude might even uncover undiagnosed POTS, as symptoms can become more noticeable in these conditions.

Living With POTS

Living with POTS has been a journey of adaptation, requiring constant vigilance and adjustment to manage a complex array of symptoms. Each new environment brings its own challenges, demanding a personalized approach to maintaining stability. My recent clinical rotation in Frisco, Colorado, situated at 9,000 feet above sea level, provided an invaluable opportunity to observe firsthand how altitude influences the physiology of POTS. An overnight stay in Denver for partial acclimatization helped mitigate some initial altitude-related exacerbations, but the first few days at higher elevation were marked by pronounced symptoms, including lightheadedness, tachycardia, and insomnia. Physically demanding activities, such as snowboarding, pushed my body to its limits, resulting in extreme fatigue and heightened tachycardia. Despite these challenges, I observed gradual improvement; by the second week, I had returned to my baseline—if not better than during my time in the heat of Phoenix, Arizona. Interestingly, the colder temperatures of the region seemed to offer symptomatic relief, likely through vasoconstriction that may enhance circulation. These experiences have deepened my understanding of POTS as a highly individualized condition, emphasizing the critical importance of lifestyle modifications, environmental considerations, and a patient-specific approach to management. My journey underscores how adaptability and tailored interventions can significantly improve functionality and quality of life for those navigating the complexities of this syndrome.

What is POTS?

Postural Orthostatic Tachycardia Syndrome (POTS) is a chronic condition characterized by an abnormal increase in heart rate upon standing. It is a form of dysautonomia, involving dysregulation of the autonomic nervous system, which balances the sympathetic (“fight or flight”) and parasympathetic (“rest and digest”) systems. The autonomic nervous system regulates involuntary bodily functions such as heart rate, blood pressure, and digestion. POTS primarily affects women, with symptoms often appearing in their teens or twenties. It is estimated to affect between 1 to 3 million people in the United States, though it is likely underdiagnosed due to lack of awareness. Under normal conditions, standing triggers the body to constrict blood vessels and slightly increase heart rate to counteract gravity’s effects. In POTS, this response is impaired, leading to blood pooling in the lower extremities and reduced blood flow to the brain. The exact cause of POTS is not fully understood, but it is commonly linked to viral infections, autoimmune conditions, genetic predispositions, small fiber neuropathy, impaired norepinephrine regulation, or hypovolemia (low blood volume). Notably, long-COVID, a range of long-term symptoms and conditions resulting from an acute COVID infection, is linked to POTS. Approximately 1% of patients with an acute COVID-19 infection go on to develop orthostatic intolerance (Cheshire, 2024). Studies also show that keeping up with COVID-19 vaccinations can prevent long-COVID.

The hallmark symptom of POTS is an excessive increase in heart rate of over 30 bpm quickly after standing (WP, 2024). Common symptoms include tachycardia, palpitations, dizziness, and fainting (syncope or near-syncope), brain fog, headaches, lightheadedness, and severe fatigue. Less common symptoms include nausea, bloating, abdominal discomfort, shakiness, and exercise intolerance. POTS symptoms are often worsened by factors such as dehydration, heat, prolonged standing, illness, or physical stress. Diagnosing POTS involves a tilt-table test which monitors heart rate and blood pressure during positional changes. Treatment for POTS focuses on improving symptoms and quality of life through lifestyle adjustments. Key components include hydration, increased salt intake, compression garments, graded exercise therapy, and psychological support. Medications such as Fludrocortisone or Midodrine, that both increase blood pressure, may be added if the provider deems it fit. The course of POTS varies widely; some individuals experience significant improvement with treatment, others may have persistent symptoms. Early diagnosis and a multidisciplinary approach can lead to better outcomes.

The Effect of Altitude on the Autonomic Nervous System

Altitude significantly influences the autonomic nervous system due to reduced oxygen levels and atmospheric pressure, which challenge the body’s ability to maintain homeostasis. At higher elevations, the sympathetic nervous system becomes more active, increasing heart rate and blood pressure to compensate for lower oxygen availability. This is because hypoxia alters chemoreceptor and baroreceptor function, leading to increased sympathetic excitation and decreased parasympathetic tone.

During a study at 4300 m, urine norepinephrine levels—a marker of sympathetic activity—peaked 4–6 days after altitude exposure (Mazzeo, 1998). The study compared women in different hormonal phases when exposed to high altitude. The urinary norepinephrine levels heart rates both increased over time in both follicular and luteal phases. The differences between the two were not statistically significant, showing that women experience sympathetic increase at altitude regardless of what phase of their cycle. This was done in comparison to a previous study showing the same findings in men (Mazzeo, 1998). 

A line graph indicating the rise follicular and luteal heart rates in beats per minute as days at altitude increase.
A line graph indicating increasing amounts per 24 hours of urinary norepinephrine.

Other physiological responses include increased ventilation, cardiac output, and heart rate. However, with acclimatization, heart rate and cardiac output typically return to sea-level values within 9–12 days (Hainsworth et al., 2007). Over time, improved oxygen-carrying capacity enhances tolerance to orthostatic stress. All in all, orthostatic tolerance during hypobaric hypoxia involves three mechanisms: cardiovascular control of heart rate and cardiac output, cerebrovascular responses to hypocapnic hypoxia (due to hyperventilation), and elevated sympathetic activity (Blaber et al., 2003). 

For individuals with POTS, altitude-related stresses may exacerbate symptoms. Hypoxia and reduced barometric pressure can worsen fatigue, brain fog, and dizziness by increasing the body’s effort to oxygenate tissues. Reduced oxygen delivery to the brain and tissues may intensify lightheadedness and syncope— which is already common in POTS.

Although acclimatization typically occurs within 1–2 weeks at altitude in healthy individuals, research on acclimatization in POTS patients is limited. Further studies are needed to determine whether individuals with autonomic dysfunction can adapt as effectively as those without.

Living With POTS at Altitude 

Living with POTS at altitude presents unique challenges that require careful management, as patients may find it harder to adapt to the altitude-induced changes in blood oxygenation and pressure regulation. These challenges are compounded by the existing difficulties they face in maintaining autonomic stability. The reduced oxygen levels and increased demands on the cardiovascular system can amplify POTS symptoms, making daily activities more difficult. Patients with POTS generally understand their triggers and have a protocol that was formulated with their provider. Such strategies include staying well-hydrated, using compression garments, increasing salt intake, decreasing alcohol and caffeine consumption, and avoiding sudden changes in posture. Also, gradual exposure to altitude helps the body adapt to the reduced oxygen and barometric pressure, minimizing symptom flares. For individuals with POTS visiting high-altitude environments, strict adherence to their treatment regimen, including lifestyle modifications and potentially pharmacologic interventions, is paramount for managing their condition effectively.

References

Blaber AP, Hartley T, Pretorius PJ (2003) Effect of acute exposure to 3,660 m altitude on orthostatic responses and tolerance. J Appl Physiol 95:591–601

Cheshire WP. (2024) Postural tachycardia syndrome. UpToDate. 

Hainsworth, R., Drinkhill, M. J., & Rivera-Chira, M. (2007). The autonomic nervous system at high altitude. Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 17(1), 13–19

Mazzeo RS, Child A, Butterfield GE, et al. (1998) Catecholamine response during 12  days of high-altitude exposure (4,300 m) in women. J Appl Physiol 84:1151–1157

Joy Plutowski is a second-year PA student born and raised in Arizona. She completed her undergraduate degree in biology at Arizona State University and is now pursuing her master’s at Midwestern University in Glendale, AZ. Before PA school, she worked as a medical scribe for an interventional cardiologist, a field she is interested in pursuing. Currently, she has the wonderful opportunity of completing her pediatrics rotation in Frisco, CO. In her free time, Joy enjoys exploring national parks, playing video games, dancing, and most recently, snowboarding. 

Acclimation, Altitude Science, Exposure, Genetics, Health, High Altitude

Boy Scouts and Skiers: Reducing the Risk of Developing Acute Mountain Sickness

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Thousands of boy scouts travel to Philmont Scout Ranch (PSR) in Cimarron, New Mexico each year in hopes of improving their wilderness survival skills by ascending its rugged, mountainous terrain. Elevations at PSR range from 2011 to 3792 m, in sharp contrast to the lower elevations the boy scouts are used to. Those with a history of daily headaches, gastrointestinal illnesses, and prior acute mountain sickness were found to be most at risk of developing altitude related illnesses while ascending PSR. The incidence of acute mountain sickness was 13.7% at PSR when participants ascended from base camp (2011 m) to 3000m+ as compared to up to 67% in other staged ascent studies [3]. Similarly to PSR, millions of people ascend the Colorado Rocky Mountains during ski season and face the same potential complications. This risk makes it abundantly important to investigate potential ways to prevent the development of altitude related illnesses.

Oxygen from inspired air (air breathed in) flows down its concentration gradient from the alveolar space into the blood, where it is carried primarily bound to hemoglobin and delivered to tissue. At high altitudes, oxygen availability and barometric pressure decrease remarkably, hindering the concentration gradient and increasing the risk of tissue hypoxia [2]. Progressive tissue hypoxia eventually leads to high altitude illnesses (HAI), which are cerebral and pulmonary syndromes resulting from rapid ascent. The likelihood of developing these disease processes can be greatly reduced if the body is given time to acclimate to the increased altitude. This is especially relevant during the holidays, when many are traveling from lower altitudes to higher altitudes abruptly for vacation or to visit with family.

This raises the question: should travelers spend the night in Denver before ascending into the mountains to allow for acclimatization and reduce the risk of HAI?

The rate of acclimatization, or the body’s ability to adjust to and accommodate increased oxygen requirement, is difficult to generalize given rate of ascension is not the only factor that influences the development of HAI. This process can take anywhere from days to potentially months depending on a number of factors including cardiopulmonary comorbidities, a history of HAI, genetics, certain medications, substance usage, and degree of physical exertion amongst others [5].

Despite the multifactorial nature of developing HAI, rate of ascent remains one of the primary risk factors. Studies have shown that spending time at moderate altitude before ascending to higher altitudes in a process called “staged ascent” decreases the likelihood of developing HAI in unacclimatized individuals [4]. A recent study conducted at the U.S. Army Research Institute of Environmental Medicine assessed incidence of acute mountain sickness (AMS, a subcategory of HAI), in unacclimatized individuals who were staged for 2 days at altitudes of 2500 m, 3000 m, and 3500 m respectively before ascending to 4300 m. Another group ascended directly to 4300 m without staging. Ultimately, the incidence of AMS was significantly lower in the staged groups than in the direct ascent group; AMS incidence in the staged groups was up to 67%, while AMS incidence in the direct ascent group was up to 83% [1].

Two graphs, A and B, illustrate the incidence of acute mountain sickness by percent at elevations of 2500m, 3000m, 3500m and a control group, as well as peak acute mountain sickness severity ranked from 0 to 2 for the same elevations and a control group.

Graphs A and B show that the incidence of AMS at 4300 m is reduced when unacclimatized individuals are staged at 2500 m, 3000 m, and 3500 m as compared to those who directly ascended to 4300 m [1].

Given the above information, unacclimatized individuals, skiers and boy scouts alike, may benefit from spending the night in Denver before coming to the mountains, as this mimics staged ascent and thus decreases the incidence of HAI.

Tall, snowy pines rise up out of powdery snow on a ski slope overlooking forests stretching out toward a range of white peaks in the distance under a sunny blue sky.
View from the top of Keystone Resort taken while snowboarding (elevation 3782 m)

References

[1] Beth A. Beidleman et al. “Acute Mountain Sickness is Reduced Following 2 Days of Staging During Subsequent Ascent to 4300m”. In: High Altitude Medicine & Biology 19.4 (2018). Published Online: 21 December 2018, pp. xxx–xxx. doi: 10.1089/ham.2018.0048. 

[2] Chris Imray et al. “Acute Mountain Sickness: Pathophysiology, Prevention, and Treatment”. In: Progress in Cardiovascular Diseases 52.6 (May 2010), pp. 467–484. doi: 10.1016/j.pcad.2009.11.003.

[3] Courtney LL Sharp et al. “Incidence of Acute Mountain Sickness in Adolescents Backpacking at Philmont Scout Ranch”. In: Wilderness and Environmental Medicine 35.4 (2024), pp. 403-408

[4] Andrew M. Luks, Erik R. Swenson, and Peter B¨artsch. “Acute high-altitude sickness”. In: European Respiratory Review 26.143 (Jan. 2017), p. 160096. doi: 10.1183/16000617.0096-2016.

[5] Michael Schneider et al. “Acute mountain sickness: influence of susceptibility, preexposure, and ascent rate”. In: Medicine & Science in Sports & Exercise 34.12 (Dec. 2002), pp. 1886–1891

Matison Miratsky is a physician assistant student who attends Midwestern University in Arizona with plans to go into OB/GYN. Before PA school, she grew up in Denver, Colorado and attended the University of Colorado at Boulder. She worked in an emergency department in Denver, then at a family medicine clinic in Arizona. Her personal interests include snowboarding, watching movies, spending time with family, and cooking.

Acclimation, Altitude Science, Backcountry, Backpacking, Health, High Altitude, Huts, Medicine, Mountaineering, Technology

New Use for Existing Technology and HAPE/HACE

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by Kaity Barker-Grasser, FNP

Ultrasound itself is not an unfamiliar technology to most, having been used in obstetrics and gynecology (OB/GYN) for many years. Newer research is now showing that ultrasound imaging may have good applicability in both high-altitude pulmonary edema (HAPE) and high-altitude cerebral edema (HACE). Pulmonary edema (or fluid in the lungs) is identified as “B-lines” or “comet tails” and is easily distinguishable on ultrasound (Gargani, 2019).

Illustration of the rib cage and clavicle bones indicating different probe positions to scan the lung using Ultrasound, accompanied by two images of lung Ultrasounds where asterisks indicate shadows of the ribs and white arrows indicating the pleural line.
Gargani, 2019

Using ultrasound to measure the diameter of the optic nerve can also assist with a diagnosis of HACE, as an increased diameter indicates increased intercranial pressure from HACE (Shookahi et al., 2020). The advantages of ultrasound over traditional imaging include being highly portable and usable in austere environments (such as back country), no radiation like many other imaging techniques, accurate for diagnosing pulmonary edema and other conditions, and takes little time for providers to master. Ultrasound also has a significant cost savings as the machine itself is relatively inexpensive, does not require special construction like adding lead to an Xray room, and is applicable in many other diagnoses (including kidney disorders, gallbladder disease, pneumonia, trauma, muscular disorders, and gynecological complaints). Ultrasound also has the capability to differentiate types of pulmonary edema, as well as other lung disorders, and generally much faster than a traditional Xray as there is no radiographic lag between clinical onset and ultrasound changes.

Three x-ray images displaying different etiologies of B-lines: cardiogenic pulmonary edema, noncardiogenic pulmonary edema, and pulmonary fibrosis.
Pulmonary Edema on Xray, Mayo Clinic, 2024

Pulmonary Edema on Xray Mayo Clinic, 2024

In HAPE, an increase in the number of B-lines indicates an accumulation of fluid in the lungs. Healthy individuals acclimating to the altitude have been shown to have a physiologic increase in B-lines during the first 4 days of high-altitude exposure as well as pregnant individuals having an increase in their baseline b-line count. Keeping these differences in mind, an increase of B-lines of more than 3 in a lung field, in more than 2 lung fields indicates an increase in extravascular lung water (EVLW) and could support a diagnosis of HAPE. Correlating this with clinical signs and symptoms of altitude sickness (HA, dizziness, fatigue, shortness of breath, nausea/vomiting), as well as HAPE (hypoxia, cough, exercise intolerance) can support a more rapid diagnosis of HAPE as well as assist with deciding need for oxygen and/or altitude descent (Yang et al., 2018; Heldeweg et al., 2022). The provider can also use the ultrasound to monitor resolution of the pulmonary edema to help support decisions to discontinue oxygen or to encourage altitude descent. Those with comorbidities such as heart failure can also be monitored for early signs that their treatment plan is not adequately addressing their EVLW and can receive correction prior to needing hospitalization (Chiu et al., 2022).

Two x-ray images of the chest from the Mayo Clinic labelled cardiogenic and HAPE/noncardiogenic from left to right.

Pulmonary Edema on Xray Mayo Clinic, 2024

HACE, as a disorder including altered mental status, ataxia, headache, loss of consciousness, and seizures, is a serious complication of high altitude. As the symptoms suggest, rapid identification is key to reducing other problems, including death, from HACE. The use of ultrasound is relatively new in assisting with diagnosis, but an increase in optic nerve diameter on ultrasound above 5 millimeters indicates that there is a good chance of brain swelling (or cerebral edema) and subsequent increased intracranial pressure. Identifying this early allows for rapid decision making the descent to a lower altitude or using a more rapid evacuation method (helicopter or rapid ground transport). Increased intracranial pressure can also result from head injury or trauma and thus can be useful in settings where an injury may have occurred. This makes this a tool that could be invaluable in search and rescue operations or for first responders (Shookahi et al., 2020).

Four Ultrasound images of the lungs illustrating use as a densitometer: different ultrasound patterns for different levels of lung aeration. Below the images, a graph indicating lung air content from 100% on the left to 0% on the right.
Gargani, 2019

Keeping these benefits in mind, remember that diagnostic imaging is a support tool and not the complete answer to all health problems. Hopefully soon we will see this tool being used with more frequency to help aid our healthcare providers in determining a more accurate cause of symptoms!

References

Chiu, L., Jairam, M. P., Chow, R., Chiu, N., Shen, M., Alhassan, A., Lo, C.-H., Chen, A., Kennel, P. J., Poterucha, T. J., & Topkara, V. K. (2022). Meta-Analysis of Point-of-Care Lung Ultrasonography Versus Chest Radiography in Adults With Symptoms of Acute Decompensated Heart Failure. The American Journal of Cardiology, 174, 89–95. https://doi.org/10.1016/j.amjcard.2022.03.022

Gargani L. (2019). Ultrasound of the Lungs: More than a Room with a View. Heart Failure Clinics, 15(2), 297–303. https://doi.org/10.1016/j.hfc.2018.12.010

Heldeweg, M. L. A., Smit, M. R., Kramer-Elliott, S. R., Haaksma, M. E., Smit, J. M., Hagens, L. A., Heijnen, N. F. L., Jonkman, A. H., Paulus, F., Schultz, M. J., Girbes, A. R. J., Heunks, L. M. A., Bos, L. D. J., & Tuinman, P. R.. (2022). Lung Ultrasound Signs to Diagnose and Discriminate Interstitial Syndromes in ICU Patients: A Diagnostic Accuracy Study in Two Cohorts*. Critical Care Medicine, 50(11), 1607–1617. https://doi.org/10.1097/ccm.0000000000005620

Mayo Clinic (2024). Pulmonary Edema. Mayo Foundation for Medical Education and Research. Retrieved February 27, 2024 from https://www.mayoclinic.org/diseases-conditions/pulmonary- edema/symptoms-causes/syc-20377009

Shokoohi, H., Pyle, M., Kuhl, E., Loesche, M. A., Goyal, A., LeSaux, M. A., Boniface, K. S., & Taheri, M. R. (2020). Optic Nerve Sheath Diameter Measured by Point-of-Care Ultrasound and MRI. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 30(6), 793–799. https://doi.org/10.1111/jon.12764

Yang, W., Wang, Y., Qiu, Z., Huang, X., Lv, M., Liu, B., Yang, D., Yang, Z., & Xie, T.. (2018). Lung Ultrasound Is Accurate for the Diagnosis of High-Altitude Pulmonary Edema: A Prospective Study. Canadian Respiratory Journal, 2018, 1–9. https://doi.org/10.1155/2018/5804942

Acclimation, Altitude Science, Child Growth & Development, Genetics, Health, High Altitude, Huts, Medicine, Summit Huts

Unveiling the Hidden Risks of Living at High Altitude on our Kidney Health, and What it Might Mean for Your Child

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The hallmark concern for the body living at high altitude is low oxygen. We breathe in less, and thus less is sent throughout our blood stream to our tissues. We are quick to think about how this affects our heart and lungs, but what about our kidneys? What are our kidneys even responsible for?

Kidneys filter, reabsorb, and excrete our blood in the form of urine. They connect our cardiovascular system with our genitourinary system. The flow through the kidneys also helps monitor and adjust our blood pressure. Their importance is truly undervalued. When they receive less oxygen than preferred (hypoxia), they will become injured. Specifically, the glomerulus (term for the filter) will become affected. When this happens, it is not efficient at filtration, and protein will spill out into our urine (proteinuria), a key feature of High Altitude Renal Syndrome (HARS).

Zooming further in below

And even further…

Another issue involves uric acid, the chemical at fault for causing gout. Due to the filter injury sustained from low oxygen, uric acid excretion is affected. It can thus build up in our musculoskeletal system and other tissues. It is famous for causing red, swollen, and painful joints. The enzyme that helps create uric acid (xanthine oxidase) is also turned on by reactive oxygen species during hypoxia. This then causes further uric acid crystal deposition in our body. This can present in patients from adolescent years through adulthood, ranging from fleeting pain to amputations from severe bone infections. We have found that for younger patients, diet plays a lesser part than genetic predisposition and hypoxia.

So how is this treated? We are still researching the best course of action. We can treat with drugs that work by inhibiting the previously specified enzyme: xanthine oxidase. These include oral allopurinol, febuxostat, and even IV pegloticase infusions. But we are primarily focused on prevention and holistic care here, so we would prefer to use supplemental oxygen therapy for those that struggle to maintain oxygen saturations in the healthy ranges. Acetazolamide is also helpful in cases. This medication works to increase our respiratory drive, helping us breathe off CO2 and breathe in more oxygen. Contact us to see what method might be right for you.

This research was brought to us by a stroke of luck. A stranger on an airplane, and a son’s coworker. This stranger happened to be a nephrologist (kidney doctor) who is studying how altitude affects the kidneys. In working with him and his team at University of Colorado Anschutz, the team at Ebert Family Clinic in Frisco, Colorado (9000′) have been ordering broader lab panels (including uric acid) for their patients and seeking those with questionable renal labs. Another patient seen by the Ebert Family Clinic team has been severely impacted by gout. With multiple amputations before the patient’s 30th birthday, this case has motivated the health care team to prevent this from happening to others in their high altitude community.

Screenshot

Carter Odean is a third-year medical student at Rocky Vista University. He was born and raised outside of Denver, Colorado before heading to Gonzaga University in Spokane, Washington where he studied biology and completed research on an invasive bee species there while playing club lacrosse. After graduating in 2019, he then came back to Denver to complete his Master’s in Biomedical Sciences at Regis University. After Regis, he started as a Clinical Research Coordinator at Anschutz Medical campus, working on multiple Diabetes Mellitus Type 2 research trials. He is in the Rural & Wilderness Track which is his favorite part about school. He plans to work as a rural Pediatrician or Family Medicine Physician. In his free time, you can find him dirt biking, fly fishing, skiing, and relaxing with friends and family. 

References

  1. Schoene, R.B. “High altitude renal syndrome: polycythemia, hyperuricemia, microalbuminuria, and hypertension.” High Alt Med Biol. 2002 Spring;3(1):65-73. doi: 10.1089/152702902753639371. PMID: 11949751.
  2. Bigham, A.W., Lee, F.S. “Tibetan and Andean patterns of adaptation to high-altitude hypoxia.” Hum Biol. 2014 Oct;86(4):321-37. doi: 10.3378/027.086.0401. PMID: 25700353; PMCID: PMC4438718.
  3. Beall, C.M., Cavalleri, G.L., Deng, L., et al. “Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders.” Proc Natl Acad Sci U S A. 2010 Mar 9;107(25):11459-64. doi: 10.1073/pnas.1002443107. Epub 2010 Feb 22. PMID: 20176925; PMCID: PMC2895106.
  4. Simonson, T.S., Yang, Y., Huff, C.D., et al. “Genetic evidence for high-altitude adaptation in Tibet.” Science. 2010 Sep 10;329(5987):72-5. doi: 10.1126/science.1189406. PMID: 20616233; PMCID: PMC3490534.
  5. Schoene, R.B., Swenson, E.R. “Cobalt-Induced Chronic Mountain Sickness: Pathophysiological Mechanisms and Genetic Susceptibility.” High Alt Med Biol. 2017 Mar;18(1):1-5. doi: 10.1089/ham.2016.0106. PMID: 28145824.Baillie, J.K., Bates, M.G., Thompson, A.A., et al. “Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude.” Chest. 2007 Dec;132(6):S275. doi: 10.1378/chest.132.6.275. PMID: 18079246.
  6. Yu, K.H., Wu, Y.J., Tseng, W.C., et al. “Risk of end-stage renal disease associated with gout: a nationwide population study.” Arthritis Res Ther. 2012 Jun 27;14(3):R83. doi: 10.1186/ar3818. PMID: 22738152; PMCID: PMC3446515.
  7. Bhat, A., Deshmukh, A., Anand, S., et al. “Acute Myocardial Infarction due to Coronary Artery Embolism in a Patient with Severe Hyperuricemia.” J Assoc Physicians India. 2019 Nov;67(11):90-91. PMID: 31801335.
  8. Khanna, D., Khanna, P.P., Fitzgerald, J.D., et al. “2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia.” Arthritis Care Res (Hoboken). 2012 Oct;64(10):1431-46. doi: 10.1002/acr.21772. PMID: 23024028.
  9. Schoene, R.B., Swenson, E.R. “Treatment of Cobalt-Induced Chronic Mountain Sickness.” High Alt Med Biol. 2017 Mar;18(1):74-77. doi: 10.1089/ham.2016.0135. PMID: 28145823.
  10. Schoene, R.B., Hackett, P.H., Henderson, W.R., et al. “High Altitude Medicine and Physiology, Fourth Edition.” CRC Press, 2007.
  11. Burtscher, M., Mairer, K., Wille, M., et al. “Risk of acute mountain sickness in tourists ascending to 4360 meters by cable car.” High Alt Med Biol. 2004 Summer;5(2):141-6. doi: 10.1089/1527029041352154. PMID: 15265307.
  12. Baumgartner, R.W., Bärtsch, P. “Chronic mountain sickness and the heart.” Prog Cardiovasc Dis. 2010 May-Jun;52(6):540-9. doi: 10.1016/j.pcad.2010.02.009. PMID: 20417390.
Acclimation, Altitude Science, Child Growth & Development, Doc Talk, Genetics, Health, High Altitude

The Frisco Score: A New Tool for Diagnosing HAPE

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by Madison Palmiero, PA-S

While HAPE may be a run-of-the-mill diagnosis for providers with years of experience practicing at altitude, it can be less straightforward for those who are unfamiliar with the condition. There are currently three recognized categories of HAPE. Classic HAPE (C-HAPE)  occurs when someone who resides at low altitude travels to high altitude and develops pulmonary edema. Re-entry HAPE (R-HAPE) occurs when high altitude residents travel to low altitude, then return to high altitude. High-altitude resident pulmonary edema (HARPE) occurs in high altitude residents without a change in altitude. HARPE is often brought on by an upper respiratory tract infection. 

HAPE and pneumonia can have similar presentations including shortness of breath, cough, fatigue, and malaise. Patients with either condition may have decreased oxygen saturation levels and abnormal findings on chest radiography. In response to this phenomena, Dr. Chris Ebert-Santos of Ebert Family Clinic in Frisco, Colorado (9000′) and Sean Finnegan, PA-C set out to develop a scoring system to differentiate the two diagnoses. If providers could easily differentiate between pneumonia and HAPE, this would shorten the time from presentation to diagnosis and would avoid unnecessary antibiotic use.

Dr. Chris and Sean Finnegan, PA-C summarized their research findings into a scoring system named the “Frisco Score”. They analyzed data from St. Anthony Summit Medical Center and associated clinics at or above ~2,760 meters above sea level from January 1, 2018 to May 30, 2023. The study looked at patients under the age of 19 who presented with hypoxemia or other respiratory concerns and had a chest x-ray performed and oxygen saturation measured. The final case review consisted of 138 total patients with 77 diagnosed with HAPE, 38 diagnosed with pneumonia, and 23 diagnosed with concomitant HAPE and pneumonia. Variables found to have no significance included gender, age, heart rate, and temperature. Variables with significance included respiratory rate, number of days ill, oxygen saturation, and chest x-ray findings. These significant variables were used to develop the Frisco Score. They do include a disclaimer that these findings are preliminary results on a small data set. Thus, as of yet, the Frisco Score should not be used on its own to make a diagnosis, but rather should be used as a clinical tool in differentiating conditions with similar presentations. 

Oxygen saturation varied greatly between patients with HAPE and those with pneumonia. Patients diagnosed with HAPE had an average oxygen saturation of 74% and those with pneumonia had an average of 92%. 

Patients who were diagnosed with HAPE had a higher average respiratory rate compared to those diagnosed with pneumonia.

 In patients diagnosed with HAPE, the duration of illness, or number of days ill, was shorter than those diagnosed with pneumonia. 

In comparison of chest x-rays, patients with HAPE were more likely to have diffuse findings and patients with pneumonia were more likely to have focal findings. 

Overall, there were no variables associated with a concomitant diagnosis of pneumonia and HAPE.

The asphalt road in the foreground leads past a sign for Common Spirit St. Anthony Summit Hospital just before the shelter over the entrance to a building labeled "ambulance" with deep green conifer forests stretching halfway up tall grey rocky mountains in the backgroundl.

In summary, patients diagnosed with HAPE had decreased oxygen saturation, increased respiratory rate, and diffuse findings on chest x-ray; while patients diagnosed with pneumonia had a longer duration of illness and focal findings on chest x-ray. The Frisco Score takes these variables into account to help differentiate a diagnosis of HAPE in children. Dr. Chris and Sean Finnegan, PA-C are currently presenting their findings at the 8th World Congress on Mountain and Wilderness Medicine in Snowbird, Utah. They hope that in the near future, the Frisco Score will be used to facilitate the diagnosis of HAPE by providers in high altitude communities state-wide.

References

1. Ebert-Santos, C. (2017). High-Altitude Pulmonary Edema in Mountain Community Residents. High Altitude Medicine & Biology, 18 (3), 278-284. https://doi.org/10.1089/ham.2016.0100

2. Ebert-Santos, C., Finnegan, S. (2024). Differentiating Pneumonia & HAPE in Children.

Altitude Science, Backpacking, Exposure, Health, High Altitude, Mountaineering, Wildlife

­­Avon skin so soft as a mosquito repellent? It’s not just an old wives’ tale!

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by Megan Furry, PA-S

The common thought that mosquitos do not live at higher elevations may no longer ring true. With temperatures slowly rising, we are seeing a rise in mosquito populations both at higher elevations and farther north than we have before.1 With the ever-changing climate, mosquitos are having luck finding their ideal conditions with standing water, higher temperature, and humidity at higher elevations.

As of June 27, 2024, the state of Colorado had already seen its first case of West Nile Virus for the year, something that does not usually occur until late in the summer; and in 2023, Colorado dealt with its worst West Nile virus outbreak ever recorded.2 As we are beginning to see more and more mosquitos in our community, people are looking for the best and safest mosquito repellents.

We all know the most common big hitters when it comes to bug spray; DEET-containing bug sprays and those that say DEET-free. If your mom is like mine and used to tell you that Avon Skin So Soft is a great mosquito repellent, I’m here to help you determine if it actually does work. A study published in the BC Medical Journal compared DEET-containing mosquito repellent, Avon Skin So Soft bath oil, and a “special mixture” containing a combination of eucalyptus oil, white vinegar, Avon Skin So Soft, and tap water, against a placebo. They found that both DEET and Avon Skin So Soft protected against mosquito bites significantly more than the “special mixture.” In this study, Avon Skin So Soft was 85% as effective as DEET at protecting against mosquito bites. Looking strictly at the numbers, DEET had 0 mosquito events (both bites and mosquitos landing on the skin), Avon Skin So Soft bath oil had 6 events, the “special mixture” had 28 events, and the placebo had 40 events.3

From personal experience, I have tested out Avon Skin So Soft and its mosquito repellent properties. In August 2019 my best friend and I ventured halfway across the world to Thailand for a post-undergraduate adventure. With limited packing room and a dislike for the smell of bug spray, I brought Avon Skin So Soft body moisturizer with me and was pleasantly surprised with how well it kept the mosquitos away. While I do recall getting just a few mosquito bites during my time there, I will definitely be bringing it with me for my next post-graduation adventure after finishing PA school.

As Colorado is seeing a rise in mosquitos earlier in the season it’s time to check our bug sprays. If you are interested in trying something new, or if you prefer DEET-free products, Avon Skin So Soft might be worth a try. With all of the hype that Avon Skin So Soft bath oil has as an effective insect repellent, the company has made a specific bug repellent line of products that claims to protect against mosquitos, deer ticks, black flies, gnats, and biting midges.

And for our furry friends that tag along with us on all of our outdoor adventures, remember that they too can get bitten by pesky insects. They are still susceptible to mosquito bites as well as ticks and fleas. At altitude we see less ticks and fleas in our communities due to the dry air, however they are still present, so it is important to protect your animals like you do yourself. Some veterinarian recommended tick and flea prevention include Simparica Trio or Nexgard chewables.

References

  1. Today E. Mosquito Migration: Study Finds More High-Altitude Dispersal of Disease Vectors in Africa. Entomology Today. Published May 5, 2023. https://entomologytoday.org/2023/05/05/mosquito-migration-more-high-altitude-dispersal-disease-vectors-africa-malaria/#:~:text=The%20studies%20leave%20no%20doubt
  2. UCHealth KKM. Colorado records first 2024 West Nile case, after worst U.S. outbreak in 2023. UCHealth Today. Published June 27, 2024. https://www.uchealth.org/today/west-nile-virus-in-colorado/
  3. Mosquito repellent effectiveness: A placebo controlled trial comparing 95% DEET, Avon Skin So Soft, and a “special mixture” | British Columbia Medical Journal. bcmj.org. https://bcmj.org/articles/mosquito-repellent-effectiveness-placebo-controlled-trial-comparing-95-deet-avon-skin-so
Accessibility, Acclimation, Backpacking, Doc Talk, Health, High Altitude

The High Altitude Doc Visits Norway

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Founder of Ebert Family Clinic in Frisco, Colorado at 9000′, Christine Ebert-Santos, MD, MPS spent a part of her Spring 2024 backpacking across Norway:

At 2,469m (8,100 feet), Galdhøpiggen mountain in Norway is not high enough to cause altitude sickness for most people. The 300 mountain peaks over 2000m make Norway a popular destination for downhill skiing and snowboarding, as well as Nordic skiing. The long days of sunshine at this latitude allow skiing in swimsuits and summer clothes in the spring.

Norway also has the largest glacier in Europe, Jostedalsbreem. Briksdalbreen is a finger of this glacier that is a short hike in the Jostedalsbreem National Park. There are 1,600 glaciers covering one percent of Norway. Several have resorts advertising summer skiing for the whole family.

View of a backseat passenger of a driver and front seat passenger looking over a navigation screen out toward a tunnel extending beyond the car windshield before them.

 

There are 900 tunnels in Norway, including the longest tunnel in the world. Compared to Eisenhower Tunnel in Colorado at 11,112 feet elevation and 1.67 miles long, Laerdal tunnel, opened in 2000, is 15 miles long with pullouts featuring colored lighting to imitate the sunrise. Some of these tunnels, like the one between the airport and downtown Oslo, go as deep as 958 feet underwater. All have phones and excellent cell phone reception. In fact, we experienced excellent reception everywhere in Norway despite the mountains and tunnels, in contrast to my sister’s house in Centennial, Colorado and many parts of Colorado.

A bright-orange-beaked puffin sits in grass amidst stones with its bright orange feet sticking out from under its black wings and white-feathered breast.

 Our last night in Norway was special. We drove two hours over narrow roads, through tunnels, over one lane bridges to Ronde Island. With a population of 150, the island is a famous bird sanctuary. We arrived just in time to see the puffins return to their nests at 8 pm.  These colorful birds spend their lifespan of 30-40 years flying over the ocean, sleeping on the waves, returning to land once a year with the same mate.

An aerial view of large, snow-capped mountains over a town down in the valley of a deep fjord with blue, sunny skies with billowy, bright clouds.

The fact that Norway provides such amazing access to even this tiny town tells me how much they respect individuals. They have an average lifespan of 83 years (76 years in the USA), universal health care, one year paid leave for parents with a new baby, universal pensions, free education through college, daycare for less than $15/day, and much more. How much do they pay in taxes, you might ask? Less than what we pay when you consider the cost of health insurance, day care, school loans, with 60% of Americans who do not have anything saved for retirement.

Automotives at Altitude, Health, Mental Health, Road Safety

Navigating the Winter Wonderland: A Survival Guide for Driving the I-70 Corridor

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Ah, winter in the Rockies – a magical time of snow-capped peaks, cozy ski lodges, and, of course, treacherous driving conditions on Interstate 70. If you’re a seasoned local, you know the drill: every time you plan a journey along this notorious stretch of road, you find yourself pondering the eternal question, “When should I brave the chaos of I-70?”

If you value your sanity (and your fender), it’s best to avoid I-70 during rush hour, weekends, and holidays. Think of it as trying to navigate through a minefield of impatient tourists and stressed-out locals – a recipe for disaster. And let’s not forget about those big snowstorms. While they may turn the landscape into a picturesque winter wonderland, they also transform I-70 into a slippery, white-knuckled nightmare. So, unless you have a burning desire to spend the night in your car, it’s probably best to wait until the plows have done their job.

You might be wondering if there’s a better time to make the trek to and from the Front Range, the plains east of the central Rockies (like Denver and the airport!). Well, the short answer is: not really. But you can prepare a survival kit to help you weather the storm – both literally and figuratively.

First on the list of essentials: water, snacks, a flashlight with charged batteries, and blankets that will keep you and your passengers warm in case you are stalled or stuck for 24 hours before you reach any kind of indoor accommodations, and a snow and ice scraper for your windows and windshield. Even in the summer, storms bring snow at high elevations, and most gas stations around the Rocky Mountains will sell them.

Do not rely on being able to keep your vehicle running over a long period of time; this is limited by gas (unless your vehicle is a Tesla, in which case it is limited by your electric charge), and falling snow clogging the exhaust pipe of a typical combustion engine can cause carbon monoxide poisoning. You never know when you might find yourself stranded in a snowbank, praying for divine intervention – or at least a passing snowplow. And speaking of emergencies, don’t forget the toilet paper for times of desperation. Trust me, when nature calls and there’s nowhere to hide, you’ll thank me for this invaluable piece of advice. Next up, make sure you have a full tank of gas and extra windshield wiper fluid. Oh, and don’t forget the shovel and snow brush. 

Let’s also talk about vehicle capabilities. If you’re lucky enough to own a 4WD or AWD vehicle, count your blessings and use them wisely. And if not, invest in a set of chains and, more importantly, learn how to put them on before you find yourself in a slippery situation. And while we’re on the subject, snow tires are worth their weight in gold when it comes to navigating storms on I-70. If you are getting a rental car, make sure it has 4WD or AWD capabilities!

On to some recommendations for staying safe on the road. Take it slow. Don’t tailgate. Leave more room than you think behind the person in front of you, because you never know when they might hit the brakes – or the black ice. When traveling downhill, downshift instead of relying on your brakes. And last but not least, don’t use cruise control in wet or snowy conditions.

Here are some pro tips from full-time residents of Summit County, Colorado, where there are several ski resorts that see millions of visitors every year:

  1. The best days to ski are often just after a blizzard passes, but the WORST times to commute are during or just after a blizzard passes. If you see a blizzard coming and want to make the most of your ski trip, push your commute up a day or two and plan to spend the blizzard AT your accommodations so getting to the fresh snow requires little or no driving. If paying more for an extra day or two of lodging isn’t in the budget, then neither is getting into an accident or having to be towed out of a ditch in a blizzard. The chances of you having to pull over or pay for lodging on the way to your destination are too high to make it worth the commute in a blizzard.
  2. Weekends are unsurprisingly packed on the highways through the mountain corridors in Colorado. Leaving early in the morning or late at night are best for avoiding traffic, but keep in mind there may be more wildlife on the highways when it’s darker out, especially in the warmer months. Weekdays are almost always better for avoiding traffic both on the highway and on the trails.
  3. Colorado Department of Transportation Safety Patrol Program does provide some courtesies to motorists that also serve to prevent and relieve traffic congestion in emergencies, including changing your flat tire, providing fuel, jump starting vehicles, clearing debris and more! Their website is one of the most comprehensive resources for your highway travel plans.
  4. In the unfortunate event you are caught driving in a storm, snow or otherwise, it is so easy to panic and start worrying you will never see the end of it. But just like any other weather pattern, it doesn’t always maintain the same intensity and will eventually pass. Delays may only be a matter of minutes or hours. So use a reliable app or website to keep tabs on how long it might be before it is safe to proceed. If you insist on driving through a storm, keep your head and tail lights on. But a good rule of thumb is if you cannot see the road markers, you probably should pull over before you end up in a ditch.
  5. When you cannot see the road markers, it will be tricky to determine where a safe space to pull off the road is. Observe where other motorists have safely pulled off the road. Large commercial vehicles are more heavily regulated than private vehicles, and they are expected to be more cautious, and large pullouts are provided to accommodate them along the Colorado highway. Look for where those trucks are pulled over while keeping a safe distance.
  6. Here’s one final pro tip you may never have considered: footwear. You may have gotten into your cozy car wearing slippers or UGGs. But imagine having to get out and change a tire or grab blankets from the trunk in the pouring rain or a foot of snow in those. If the weather’s looking unstable, have a pair of shoes or boots you feel comfortable being outside in. (And don’t put them in the trunk.)

Useful links:

Weather, road conditions & closures, cameras: https://www.cotrip.org/home

@i70things on Instagram

https://www.codot.gov/programs/dmo/real-time-operations/traffic-incident-management/safetypatrol

Claire Bice is a physician assistant student who attends Rocky Mountain University of Health Professions in Utah with plans to go into emergency medicine and volunteer for search and rescue. Before PA school, she grew up in Visalia, California and then lived in Colorado her entire adult life. She attended University of Colorado at Boulder, worked at a dermatology office in Denver, then ski patrolled locally here at Copper Mountain. Her personal interests include snowboarding, mountain biking, live music, and taking her Australian shepherd on adventures!

Acclimation, Altitude Science, Asthma, Child Growth & Development, COVID-19, Doc Talk, Exposure, Genetics, Health, High Altitude, Medicine, Mountaineering, Pandemic, Sleep at Altitude, Technology

Can I Ever Go Back Up To High Altitude Again? – Recurrence Risk of HAPE & HARPE

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by Taylor Kligerman, PA-S

Can I ever return to high altitude? Do I need to move down to a lower elevation?

Disease processes often differ at high altitudes. Some conditions have only been known to occur at high elevations. Most of the resources cited in this blog refer to ‘high altitude’ being at or above 2,500 meters or 8,200 feet.

Ebert Family Clinic in Frisco, Colorado is at 9,075 ft. Many areas in the immediate vicinity are over 10,000′, with some patients living above 11,000′. Two of the more common conditions seen in patients at Ebert Family Clinic are high altitude pulmonary edema (HAPE) and high altitude resident pulmonary edema (HARPE), similar conditions that affect slightly different populations in this region of the Colorado Rocky Mountains.

In “classic” HAPE, a visitor may come from a low-altitude area to Frisco on a trip to ski with friends. On the first or second day, the person notices a nagging cough. They might wonder if they caught a virus on the plane ride to Denver. The cough is usually followed by shortness of breath that begins to make daily tasks overwhelmingly difficult. One of the dangerous aspects of HAPE is a gradual onset leading patients to believe their symptoms are caused by something else. A similar phenomenon is seen in re-entry HAPE, where a resident of a high altitude location travels to low altitude for a trip and upon return experiences these same symptoms [1].

In HARPE, a person living and working here in Frisco may be getting ill or slowly recovering from a viral illness and notices a worsening cough and fatigue. These cases are even more insidious, going unrecognized, and so treatment is sought very late. Dr. Christine Ebert-Santos and her team at Ebert Family Clinic hypothesize that while residents have adequately acclimated to the high-altitude environment, the additional lowering of blood oxygen due to a respiratory illness with inflammation may be the inciting event in these cases.

In both cases, symptoms are difficult to confidently identify as a serious illness versus an upper respiratory infection, or simply difficulty adjusting to altitude. For this reason, Dr. Chris recommends that everyone staying overnight at high altitude obtain a pulse oximeter. Many people became familiar with the use of these instruments during the COVID-19 pandemic. The pulse oximeter measures what percent of your blood is carrying oxygen. At high altitude, a healthy level of oxygenation is typically ≥90%. This is an easy way to both identify potential HAPE/HARPE, as well as reassure patients they are safely coping with the high-altitude environment [2].

HAPE and HARPE are both a direct result of hypobaric hypoxia, a lack of oxygen availability at altitude due to decreased atmospheric pressures. At certain levels of hypoxia, we observe a breakdown in the walls between blood vessels and the structures in lungs responsible for oxygenating blood. The process is still not totally understood, but some causes of this breakdown include an inadequate increase in breathing rates, reduced blood delivered to the lungs, reduced fluid being cleared from the lungs, and excessive constriction of blood vessels throughout the body. These processes cause fluid accumulation throughout the lungs in the areas responsible for gas exchange making it harder to oxygenate the blood [3].

We do know that genetics play a significant role in a person’s risk of developing HAPE/HARPE. Studies have proposed many different genes that may contribute, but research has not, so far, given healthcare providers a clear picture of which patients are most at-risk. Studies have shown that those at higher risk of pulmonary hypertension (high blood pressure in the blood vessels of your lungs), are more likely to develop HAPE [4]. This includes some types of congenital heart defects [5,6]. High blood pressures in the lungs reach a tipping point and appear to be the first event in this process. However, while elevated blood pressures in the lungs are essential for HAPE/HARPE, this by itself, does not cause the condition. The other ingredient necessary for HAPE/HARPE to develop is uneven tightening of the blood vessels in the lungs. When blood vessels are constricted locally, the blood flow is shifted mainly to the more open vessels, and this is where we primarily see fluid leakage. As the blood-oxygen barrier is broken down in these areas, we may also see hemorrhage in the air sacs of the lungs [3].

One observation healthcare providers and scientists have observed is that HAPE/HARPE can be rapidly reversed by either descending from altitude or using supplemental oxygen. Both strategies increase the availability of oxygen in the lungs, reducing the pressure on the lungs’ blood vessels by vasodilation, quickly improving the integrity of the blood-oxygen barrier.

In a preliminary review of over 100 cases of emergency room patients in Frisco diagnosed with hypoxemia (low blood oxygen content) Dr. Chris and her team have begun to see trends that suggest the availability of at-home oxygen markedly reduces the risk of a trip to the hospital. This demonstrates that patients with both at-home pulse oximeters and supplemental oxygen have the capability to notice possible symptoms of HAPE, assess their blood oxygen content, and apply supplemental oxygen if needed. This stops the development of HAPE/HARPE before damage is done in the lungs. In the case of many of our patients, these at-home supplies prevent emergencies and allow patients time to schedule an appointment with their primary care provider to better evaluate symptoms.

Additionally, Dr. Chris and her team have observed that patients with histories of asthma, cancer, pneumonia, and previous HAPE/HARPE are often better educated and alert to these early signs of hypoxia and begin treatment earlier on in the course of HAPE/HARPE, reducing the relative incidence identified by medical facilities. There are many reasons to seek emergent care such as low oxygen with a fever. Patients with other existing diseases causing chronically low oxygen such as chronic lung disease may not be appropriately treated with  supplemental oxygen, although this is a very small portion of the population. Discussions with healthcare providers on the appropriate prevention plan for each patient will help educate and prevent emergency care visits in both residents and visitors.

A young child with short brown hair and glasses with dark, round frames wears a nasal canula for oxygen.

Studies of larger populations have yet to be published. A review of the case reports in smaller populations suggests that the previously estimated recurrence rate of 60-80% is exaggerated. This is a significant finding as healthcare providers have relied on this recurrence rate to make recommendations to their patients who have been diagnosed with HAPE. A review of 21 cases of children in Colorado diagnosed with HAPE reported that 42% experienced at least one recurrence [7]. This study was conducted by voluntary completion of a survey by the patients (or their families) which could lead to significant participation bias affecting the results. Patients more impacted by HAPE are more likely to complete these surveys. Another study looking at three cases of gradual re-ascent following an uncomplicated HAPE diagnosis showed no evidence of recurrence. The paper also suggested there may be some remodeling of the lung anatomy after an episode of HAPE that helps protect a patient from reoccurrence [8]. Similar suggestions of remodeling have been proposed through evidence of altitude being a protective factor in preventing death as demonstrated by fatality reports from COVID-19[9].

Without larger studies and selection of participants to eliminate other variables like preexisting diseases, we are left to speculate on the true rate of reoccurrence based on the limited information we have. Strategies to reduce the risk of HAPE/HARPE such as access to supplemental oxygen, pulse oximeters, and prescription medications [10] are the best way to prevent HAPE/HARPE. Research should also continue to seek evidence of individuals most at risk for developing HAPE/HARPE [11].

A woman with reddish-brown, straight hair just below her shoulders, wears a white coat over a mustard-colored shirt, smiling.

Taylor Kligerman is a third-year medical student at Rocky Vista University with plans to complete a residency in emergency medicine. She was born and raised in Flossmoor, IL, and became interested in medicine following her first medical mission trip to Gonaïves, Haiti in 2010. Taylor has extensive experience in wilderness and remote emergency medicine. Before starting medical school, she was certified as a wilderness EMT and gained experience in remote areas of Canada and Western North Carolina on whitewater expeditions and as a volunteer with local search and rescue. Her personal interests include camping, skiing, and all paddle sports.

References

  1. Ucrós S, Aparicio C, Castro-Rodriguez JA, Ivy D. High altitude pulmonary edema in children: A systematic review. Pediatr Pulmonol. 2023;58(4):1059-1067. doi:10.1002/ppul.26294
  2. Deweber K, Scorza K. Return to activity at altitude after high-altitude illness. Sports Health. 2010;2(4):291-300. doi:10.1177/1941738110373065
  3. Bärtsch P. High altitude pulmonary edema. Med Sci Sports Exerc. 1999;31(1 Suppl):S23-S27. doi:10.1097/00005768-199901001-00004
  4. Eichstaedt C, Benjamin N, Grünig E. Genetics of pulmonary hypertension and high-altitude pulmonary edema. J Appl Physiol. 2020;128:1432
  5. Das BB, Wolfe RR, Chan K, Larsen GL, Reeves JT, Ivy D. High-Altitude Pulmonary Edema in Children with Underlying Cardiopulmonary Disorders and Pulmonary Hypertension Living at Altitude. Arch Pediatr Adolesc Med. 2004;158(12):1170–1176. doi:10.1001/archpedi.158.12.1170
  6. Liptzin DR, Abman SH, Giesenhagen A, Ivy DD. An Approach to Children with Pulmonary Edema at High Altitude. High Alt Med Biol. 2018;19(1):91-98. doi:10.1089/ham.2017.0096
  7. Kelly TD, Meier M, Weinman JP, Ivy D, Brinton JT, Liptzin DR. High-Altitude Pulmonary Edema in Colorado Children: A Cross-Sectional Survey and Retrospective Review. High Alt Med Biol. 2022;23(2):119-124. doi:10.1089/ham.2021.0121
  8. Litch JA, Bishop RA. Reascent following resolution of high altitude pulmonary edema (HAPE). High Alt Med Biol. 2001;2(1):53-55. doi:10.1089/152702901750067927
  9. Gerken J, Zapata D, Kuivinen D, Zapata I. Comorbidities, sociodemographic factors, and determinants of health on COVID-19 fatalities in the United States. Front Public Health. 2022;10:993662. Published 2022 Nov 3. doi:10.3389/fpubh.2022.993662
  10. Luks A, Swenson E, Bärtsch P. Acute high-altitude sickness. European Respiratory Review. 2017;26: 160096; DOI: 10.1183/16000617.0096-2016
  11. Dehnert C, Grünig E, Mereles D, von Lennep N, Bärtsch P. Identification of individuals susceptible to high-altitude pulmonary oedema at low altitude. European Respiratory Journal 2005;25(3):545-551; DOI: 10.1183/09031936.05.00070404
Accessibility, Acclimation, Altitude Science, Asthma, Child Growth & Development, Doc Talk, Exposure, Genetics, Health, High Altitude, Medicine

Hypoxia in the Emergency Department: Preliminary Analysis of Data from the Highest Atitude Population in North America & Children with Hypoxia

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Hypoxia is a common presentation at the emergency department for the St Anthony Summit Medical Center, located at 2800 meters above sea level (msl) in Colorado. Children under 18 are brought in with respiratory symptoms, trauma, congenital heart and lung abnormalities, and high altitude pulmonary edema (HAPE). Many complain of shortness of breath and/or cough and are found to be hypoxic, defined as an oxygen saturation below 89% on room air for this elevation. Patients who live at altitude may perform home pulse oximetry and arrive for treatment and diagnosis of known hypoxia. Extensive and ongoing analysis of the data from children found to be hypoxic in the emergency department raises many questions, including how residents vs nonresidents present, how often  these cases are preceded by febrile illness and what chief complaint is most frequently cited. 

Understanding the presentation of hypoxia in children at altitude can help ensure that healthcare providers are following a comprehensive approach with awareness of the overlapping symptoms of HAPE, pneumonia and asthma. Below is a graphic summary of 36 cases illustrating the clinical, social and geographic factors contributing to hypoxia at altitude in residents and visitors. A further analysis of over 200 children with hypoxia presenting to the emergency room at 9000 feet is underway including x-ray findings.

The graphs below were created by the author, using data extracted directly from a review of patient charts (specifically, those of children presenting to the local hospital in Summit County, Colorado (9000 feet) with hypoxia).

Graphs 1-4 show chief complaints of cough (CC) and shortness of breath (SOB) compared by age and by residence (residence includes altitudes above 2100 msl, the front range (a high altitude region of the Rocky Mountains running north-south between Casper, Wyoming and Pueblo, Colorado) averaging 1500 msl, and out of the state of Colorado) 

A graph of age with blue bars Description automatically generated
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A graph of a bar chart Description automatically generated with medium confidence

Graphs 5-6 show presence of fever by residence and by age 

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Graphs 7-8 show presence of asthma by residence and by age 

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Graphs 9 and 10 show lowest oxygen by age at admission and lowest O2 organized by days spent in the county (residents are excluded from this data). 

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A graph with blue dots Description automatically generated

Erin Snyder is a new graduate physician assistant who graduated this fall after spending her final rotation in Frisco with the Ebert clinic. She is now working in pediatric hematology at Children’s Hospital Colorado. And her free time she enjoys skiing, hiking and spending time with her cat Charlie.

Information and discussion for visitors and residents at high elevations.