Monthly Archives: October 2019

Acclimation, Altitude Science, Genetics, Health, High Altitude, High Altitude Training & Fitness, Medicine, Sickle Cell

Sickle Cell Anemia at Altitude: a Case Report

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Martin, a 27-year-old African American male, presents to a rural mountain hospital with complaints of left upper quadrant abdominal pain. Martin arrived at altitude (9,400 feet) two days ago from Oklahoma City after a 12-hour drive. Shortly after arriving to his condo in the mountains, Martin developed a dull aching pain to his left upper quadrant. The pain is constant but radiates to his L flank intermittently. Martin tried snowboarding today but had to end his day early because the pain became too severe. Martin cannot identify any aggravating or relieving factors and states that ibuprofen “didn’t even touch the pain.” Martin denies associated nausea, vomiting, diarrhea, constipation, urinary symptoms, fevers, chills, enlarged lymph nodes, or fatigue. His medical history is significant sickle cell trait without active disease. He has a negative surgical history, takes no daily medications, and has no known allergies. *

Differential diagnoses considered include kidney stones, pancreatitis, gastritis, diverticulitis, splenic enlargement, an infarcted spleen, or mononucleosis. Laboratory tests ordered include a complete blood count, reticulocyte count (indicator of immature red blood cells production), lactate dehydrogenase (an indicator of red blood cell destruction), haptoglobin (a binding protein that binds free hemoglobin after red blood cell destruction), a complete metabolic panel, and a urine analysis. A CT scan of the abdomen with contrast was also ordered and performed. 

Martin’s results showed an elevated white blood cell count, sickled cells on his blood smear, mildly elevated reticulocyte count and lactate dehydrogenase, low haptoglobin, and an elevated bilirubin. The remainder of his blood work was unremarkable. The CT scan showed a 40% infarction of his spleen. Martin was treated with oxygen, fluids, and IV pain medication and was promptly transferred to a larger hospital at lower elevation. 

What caused all of this to happen? 

Sickle cell anemia (SCA) is a mutation of the HBB gene that affects the development of normal hemoglobin, the major oxygen transporting protein in the body. SCA is an autosomal recessive genetic disorder which means that two copies of the abnormal gene have to be passed on from both parents in order for the disease to be active in the offspring. So, in other words, if both parents are carriers of the abnormal gene, their offspring have a 25% chance of developing the active disease and a 50% chance of becoming carriers themselves. 

http://www.healthnucleus

The hemoglobin protein is made up of four subunits, 2 alpha-globin and 2 beta-globin. Sickle cell carriers will have a mutation of one of the beta-globin units, resulting in no clinical manifestations of the disease. These individuals live normal lives and are virtually unaffected by the mutation, as seen in Martin’s case. Individuals with active disease will have a mutation in both of the beta-globin subunits, creating sickling of their red blood cells. Sickling of red blood cells makes them less flexible in maneuvering through the vasculature, ultimately resulting in a blockage of blood flow to various tissues in the body. This is cause of severe pain that many individuals experience when in crisis. Sickled cells are also more prone to destruction leading to an anemic state and are inefficient oxygen transporters. 

https://www.flickr.com/photos/nihgov/27669979993

The sickle cell mutation is typically found in certain ethnic groups which is thought to be related to the protective quality of sickled cells from the development of Malaria. The ethnic groups most likely to be affected include African Americans, Sub-Saharan Africans, Latinos, Indians, Individuals from Mediterranean descent, and those from the Caribbean. 

But if Martin was a carrier without active disease, why did he develop sickle cell anemia?

Individuals with the sickle cell trait can cause their cells to sickle under extreme stress including during strenuous exercise, severe dehydration, and when at high altitude. The resulting consequence is the manifestation of all of the symptoms of active disease. Although Martin had never had any symptoms related to his sickle cell trait, he was now in full sickle cell crisis that required immediate intervention. 

What are the implications? 

Individuals from any of the ethnic groups listed above should be tested for the sickle cell trait to ensure they are not carriers. A carrier must exercise extreme caution in ascending to high altitude, should stay well hydrated, and avoid strenuous exercise to prevent the development of a sickle cell crisis. 

*Case scenario is not based on any individual patient rather a compilation of varying presentations seen in the emergency department. 

Liya is 3rd year Doctor of Nursing Practice Student attending North Dakota State University. She lives in Breckenridge, Colorado and works as a registered nurse in the Emergency department. Liya was born in Latvia and moved to the United States in 1991 with her family. She grew up in the Washington, DC area until she moved to Colorado in 2012.  She is passionate about helping immigrant families and other underserved individuals gain access to basic healthcare services. She hopes to work in Family Medicine in a federally qualified health center in the Denver metro or surrounding areas. In her spare time, Liya enjoys hiking, snowboarding, biking, and camping. 

References

Adewoyin A. S. (2015). Management of sickle cell disease: A review for physician education in Nigeria (sub-Saharan Africa). Anemia, 2015. doi:10.1155/2015/791498

American Society of Hematology. (n.d). Sickle cell trait. Retrieved from https://www.hematology.org/Patients/Anemia/Sickle-Cell-Trait.aspx

Mayo Clinic. (2018). Sickle cell anemia. Retrieved from https://www.mayoclinic.org/diseases-conditions/sickle-cellanemia/symptoms causes/syc-20355876

U.S National Library of Medicine. (2019). Sickle cell disease. Retrieved from https://ghr.nlm.nih.gov/condition/sickle-celldisease#inheritance

Yale, S.H,, Nagib, N., & Guthrie, T. (2000). Approach to the vasoocclusive crisis in adults with sickle cell disease. American Family Physicians, 61(5), 1349-1356. Retrieved from https://www.aafp.org/afp/2000/0301/p1349.html

Health, High Altitude, Mental Health, Mountaineering

Mental Health at Altitude

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Last year, 20% of U.S. adults experienced a mental health disorder (CDC). Mental illness is a leading cause of disease burden worldwide, and therefore, needs to be talked about. Mental health conditions, such as depression, anxiety, bipolar disorder, eating disorders, schizophrenia, drug/alcohol abuse, etc., have devastating consequences on the individual’s quality of life and overall wellbeing. Mental illness emerges from a complex interplay of genetic, psychological, lifestyle, and environmental factors. Environmental exposure is important to consider when looking at mental health, especially at high altitude. Up in the mountains, we must consider oxygen availability on the impact of our mental wellbeing. 

Numerous studies have shown rates of depression and suicide to be higher at high elevations (Figures 1 & 2), even when controlling for other variables such as socioeconomic status and demographics (Kim et al., 2014).

Why is this?

Some researchers propose that low blood oxygen levels from lower atmospheric pressure at altitude (called hypobaric hypoxia) has something to do with it. Animal studies done on rats and short term human studies have found this connection (Kanekar, 2015), and altering brain bioenergetics and serotonin metabolism could have something to do with it. Both pathways are affected by depression, and both are affected by hypoxia (Hwang, 2019). Hypoxia may lead to suppressed mitochondrial functioning, resulting in a change of how our cerebrum uses its energy. Patients with depression have a harder time using energy in their pre-frontal cortex, which makes it harder to concentrate and fight off negative thoughts. If this is already the case at low altitude, being at higher altitude may make moods more unstable and focus even harder to obtain. 

Second, hypoxia may lead to decreased serotonin levels in the brain, which is a very important neurotransmitter targeted in the treatment of anxiety and depression. These medications, known as SSRIs (selective serotonin reuptake inhibitors) allow more serotonin to hang around in the brain. If normal antidepressants are less effective at elevation, we need to take another look at the current treatment plan. Researchers are looking into a medication that is a precursor to serotonin that bypasses the oxygen-dependent phase of the reaction. It is called 5-hydroxytryptophan. Creatine monohydrate may also be effective in treating depression at altitude (Ramseth, 2019). This is an exciting opportunity in mental health at altitude research; one that may yield more effective treatment for people living in the mountains.

However, we cannot be certain that high altitude is causing the increased rates of depression and suicide (Reno, 2018). After all, correlation does not equal causation. There are multiple confounding variables at play, such as population density, characteristics of suicide victims, access to health care, religious beliefs, and ownership and access to firearms. Even though we do not know the cause, the correlation is clear. Because of this, clinical professionals at high altitudes need to be vigilant when exploring this concern with patients. 

Looking at the flip side, multiple studies support positive effects of altitude on mental health. It is well known that physical activity is good for your body and mind. In general, exercise improves symptoms of anxiety, depression, and panic disorder, in addition to increasing quality of life and resilience (Hufner, 2018). An interesting report found that physical activity in the mountains has even more benefits on mental health than exercise at sea level (Ower et al., 2018). This was found to be because building a personal bond to an individual mountain enhances the positive effect of the outdoors on mental health. Think about that the next time you look up at a mountain you once stood on top of. In addition, a mountain hiking program in the Alps has been shown to improve hopelessness, depression, and suicidal ideation when added on to usual care in patients who were at high risk for suicide (Sturm et al., 2012). Programs like these utilize high altitude in a positive way to treat mental health conditions.

Overall, mental health at high altitude is a complex topic that needs more research. The most important thing we must all remember is to seek help when we need it, and to never feel ashamed if you are struggling with a mental health concern. Remember: You are doing your best. 

If you or a loved one are in a crisis but don’t know where to turn, consider calling Colorado Crisis Service toll-free at 1-844-493-TALK (8255) or text TALK to 38255 to speak to a trained professional.

If you are interested in hearing more about this topic, here is an interview with reporter Rae Ellen Bichelle on NPR news discussing mental health at altitude:

https://www.npr.org/player/embed/752292543/752292544

Maggie Schauer is a 2nd year PA student studying at Des Moines University. She is from Pewaukee, WI and obtained her bachelor’s degree in psychology at UW-La Crosse. After completing her pediatrics rotation at Ebert Family Clinic, Maggie will be going around the Midwest until her final international medicine rotation in Belize! She loves cheese, the Packers, hiking, running, waterskiing, and almost anything outdoors. Her current plan is to become a physician assistant in psychiatry and live somewhere exciting (like the mountains), until eventually moving back to Wisconsin. Her dream is to hike every 14er in Colorado; she currently has two under her belt: Grays and Torreys.

References:

  1. Ha, H., & Tu, W. (2018). An Ecological Study on the Spatially Varying Relationship between County-Level Suicide Rates and Altitude in the United States. International journal of environmental research and public health, 15(4), 671. 
  2. Hufner, K., Sperner-Unterweger, B., & Brugger, H. (2019). Going to Altitude with a Preexisting Psychiatric Condition. High Altitude Medicine & Biology, 20(3).
  3. Hwang, J., DeLisi, L. E., Öngür, D., Riley, C., Zuo, C., Shi, X. , Sung, Y. , Kondo, D. , Kim, T. , Villafuerte, R. , Smedberg, D. , Yurgelun‐Todd, D. and Renshaw, P. F. (2019), Cerebral bioenergetic differences measured by phosphorus‐31 magnetic resonance spectroscopy between bipolar disorder and healthy subjects living in two different regions suggesting possible effects of altitude. Psychiatry Clin. Neurosci., 73: 581-589.
  4. Kanekar, S., Bogdanova, O., Olson, P., Sung, Y., D’Anci, K. Renshaw, K. (2015). Hypobaric Hypoxia Induces Depression-like Behavior in Female Sprague-Dawley Rats, but not in Males. High Altitude Medicine & Biology; 16 (1)
  5. Kim, J., Choi, N., Lee, Y. J., An, H., Kim, N., Yoon, H. K., & Lee, H. J. (2014). High altitude remains associated with elevated suicide rates after adjusting for socioeconomic status: a study from South Korea. Psychiatry investigation, 11(4), 492–494.
  6. Ramseth, L. (2018, July 1). University of Utah research shows high altitude linked to depression and suicidal thoughts. In The Salt Lake Tribune. Retrieved October 17, 2019.
  7. Reno, Elaine, et al. (2018). Suicide and High Altitude: An Integrative Review. High Altitude Medicine & Biology, 19(2).
Health, High Altitude, Medicine, Mountaineering, Parkinsons

Open Call for Interviews on Parkinson’s at Altitude

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Earlier this year, our students published some articles on Parkinson’s disease at altitude. One was an account of patients experiencing some relief from their symptoms at high altitude, and another involved a local couple in our region of the Rockies.

We’ve since received a lot of attention to these articles specifically and would like to hear from more people who have any feedback to share about their experience at altitude with Parkinson’s disease.

Feel free to send us an e-mail – admin@ebertfamilyclinic.com

Acclimation, Alcohol at Altitude, Altitude Science, Child Growth & Development, Health, High Altitude, High Altitude Training & Fitness, Medicine, Mountaineering, Technology

The Legacy of the Mountain Guru: Prof. Dr. Gustavo Zubieta-Castillo

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We’ve published a series of accounts from Dr. Chris’s recent attendance at the 7th Annual Chronic Hypoxia conference in La Paz, Bolivia , conducted by Dr. Gustavo Zubieta-Castillo. He is one of the world’s leading experts of altitude medicine and Dr. Chris’s collaboration and contact with him has added literally phenomenal insight into our own high altitude research.

Dr. Chris “en Teleférico” with fellow altitude researchers Vanessa Moncada, Diana Alcantara Zapata, Dzhunusova G. S., Oscar Murillo, and Alex Murillo. Photo courtesty of Dr. Zubieta-Castillo.

There is something literarily romantic about the scientists who are compelled to remind you, “I’m not crazy!” Dr. Zubieta-Castillo has held soccer games at 6,542 m (21,463′), proving the remarkable adaptability of the human body. He maintains a high altitude training lab, called the Chacaltaya Pyramid, at 5,250 m (17,224′). In his recent video (below), he illustrates the connection between longevity and elevation, where citizens of the highest cities in South America live to be well over 100.

It’s notable that a city known for its wine at 2,790 m (9,153′), called Chuquisaca, boasts some of the oldest residents. Not surprisingly, our research has led us to some speculation on the relationship between alcohol and the body at altitude. Additionally affirming is Dr. Zubieta-Castillo’s father, nicknamed “El Guru de la Montaña”, who began his legacy of altitude research and medicine by examining the hearts of dogs at altitude (sound familiar? See our article on Dogs at Altitude), as well as Dr. Zubieta-Castillo’s own testament that asthma can be and has been treated by altitude (see Asthma at Altitude).

His latest correspondence with Dr. Chris and their mutual colleagues reads like letters written by history’s greatest scientists, beginning,

Dear Colleague Scientists:

The 7th Chronic Hypoxia Symposium, thanks to your outstanding participation was a great success !! We shared great scientific, friendship and enthusiasm from 16 countries, along with travel and conferences in fascinating environments, all at high altitude.

The letter ends with an invitation to all colleagues to contribute their own research to the first chronic hypoxia-dedicated issue in a top medical journal, so be on the lookout for Dr. Chris’s contribution (which we will be sure to share here).

The video below is a fascinating look into some of Dr. Zubieta-Castillo’s latest research, including his theories and recommendations on conditioning humans in space with hypoxia, a dissertation that was initially dismissed as irrelevant, then subsequently published. Enjoy!

robert-ebert-santos

Roberto Santos is from the remote island of Saipan, in the Commonwealth of the Northern Mariana Islands. He has since lived in Japan and the Hawaiian Islands, and has made Colorado his current home, where he is a web developer, musician, avid outdoorsman and prolific reader. When he is not developing applications and graphics, you can find him performing with the Denver Philharmonic Orchestra, snowboarding Vail or Keystone, soaking in hot springs, or reading non-fiction at a brewery.

Acclimation, Health, High Altitude, High Altitude Training & Fitness

Can Living at Altitude Alone Improve Your Health?

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There has been a lot of speculation among all the locals and visitors up here, even the students who do rotations with us, on whether merely living at altitude can yield health and/or fitness benefits. And this is a conversation that has been going on for quite some time.

At our clinic, what we’ve been finding over these past two decades of our practice and research is that the way individuals respond to altitude is not so simple. Yes, in many cases of acute mountain illness we see, the remedy may simply be more oxygen, whether that means being hooked up to an oxygen concentrator or descending in elevation. But the answer to whether living at high altitude will improve your health and/or fitness in itself is much more complex.

Studies have been and continue to be conducted all over the globe, not surprisingly in other countries with high-altitude communities like India, Nepal, Argentina, and Bolivia (you may remember Dr. Chris’s accounts of the Chronic Hypoxia conference she attended earlier this year in La Paz). An article in Berkley Wellness from 2014, Are Higher Elevations Healthier?, cites some speculation that appetite may be suppressed at higher elevations because of the effect it has on hormones like leptin, and that the added physical exertion required for your body to function in an environment with lower oxygen may also require more calories.

Sure. This is consistent with some of our own speculation at Ebert Family Clinic. But there is so much more to it.

Hiking rations up to one of Colorado’s remote mountain huts.

Altitude does demand a lot from the body. Bodies born and raised up here tend to be more well-adapted. Bodies not born, but raised up here certainly have a great chance at achieving more advanced levels of acclimatization. Healthy bodies that come up to altitude on occasion may experience little to no symptoms of mountain illness. But as soon as a pre-existing respiratory or cardiovascular condition comes into play, all bets are off, and the high altitude can become more of a threat than an asset.

On the other hand, we’ve also seen some recent studies (and personal accounts from patients and readers) that indicate certain conditions may experience relief from various symptoms at higher elevations (see Altitude As Asthma Treatment or Increasing the Altitude to Decrease the Symptoms of Parkinsons). And there are many other variables here besides the elevation, like air and water quality or culture. Summit County’s population is consistently rated among the healthiest, most long-lived in the country. But how much does the culture of outdoor activity influence that? And how does the popularity of craft beer and marijuana use affect that? Is there a “typical” diet up here?

Somewhere in Eagle County, CO.

The way each individual body acclimatizes depends on so many physiological factors and fine processes. Very generally, the better your body carries out these processes, the easier your life at altitude will be. With this in mind, it might seem that those who thrive at altitude are already in good shape, while those who are prone to the most difficult transitions may very well be fighting other inhibiting factors already.

It would seem that for every accommodation your body makes at altitude that may benefit its function at sea level, there are other compromises. We’ve heard from more than one athlete that muscle training at altitude may not be as effective, because your cardiovascular and respiratory capacity will max out before you reach the limit of your strength. We’re also finding that blood oxygen saturation levels may be lower at altitude for many people while sleeping. While lower oxygen may stimulate some beneficial transformation in the body (increased red blood cell counts, for example), it may also very quickly complicate body function under certain conditions. In addition to all that, there is a strong genetic factor to an individual’s response to altitude that we still have much to learn about.

robert-ebert-santos

Roberto Santos is from the remote island of Saipan, in the Commonwealth of the Northern Mariana Islands. He has since lived in Japan and the Hawaiian Islands, and has made Colorado his current home, where he is a web developer, musician, avid outdoorsman and prolific reader. When he is not developing applications and graphics, you can find him performing with the Denver Philharmonic Orchestra, snowboarding Vail or Keystone, soaking in hot springs, or reading non-fiction at a brewery.